| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUEDC2 | ESR1 | ENSP00000358953 | ENSP00000405330 | CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.472 |
| CUEDC2 | LMTK3 | ENSP00000358953 | ENSP00000270238 | CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | 0.535 |
| ESR1 | CUEDC2 | ENSP00000405330 | ENSP00000358953 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism | 0.472 |
| ESR1 | LMTK3 | ENSP00000405330 | ENSP00000270238 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | 0.577 |
| FREM3 | FRG2C | ENSP00000332886 | ENSP00000312299 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | Protein FRG2-like-2; FSHD region gene 2 family member C | 0.559 |
| FREM3 | LMTK3 | ENSP00000332886 | ENSP00000270238 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | 0.488 |
| FREM3 | UBN2 | ENSP00000332886 | ENSP00000418648 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family | 0.504 |
| FREM3 | ZNF594 | ENSP00000332886 | ENSP00000382513 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | Zinc finger protein 594; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.524 |
| FRG2C | FREM3 | ENSP00000312299 | ENSP00000332886 | Protein FRG2-like-2; FSHD region gene 2 family member C | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | 0.559 |
| FRG2C | LMTK3 | ENSP00000312299 | ENSP00000270238 | Protein FRG2-like-2; FSHD region gene 2 family member C | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | 0.554 |
| FRG2C | UBN2 | ENSP00000312299 | ENSP00000418648 | Protein FRG2-like-2; FSHD region gene 2 family member C | Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family | 0.575 |
| FRG2C | ZNF594 | ENSP00000312299 | ENSP00000382513 | Protein FRG2-like-2; FSHD region gene 2 family member C | Zinc finger protein 594; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.621 |
| HERC1 | LMTK3 | ENSP00000390158 | ENSP00000270238 | Probable E3 ubiquitin-protein ligase HERC1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; WD repeat domain containing | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | 0.461 |
| HOOK2 | LMTK3 | ENSP00000380785 | ENSP00000270238 | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | 0.703 |
| LMTK3 | CUEDC2 | ENSP00000270238 | ENSP00000358953 | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism | 0.535 |
| LMTK3 | ESR1 | ENSP00000270238 | ENSP00000405330 | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.577 |
| LMTK3 | FREM3 | ENSP00000270238 | ENSP00000332886 | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | 0.488 |
| LMTK3 | FRG2C | ENSP00000270238 | ENSP00000312299 | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | Protein FRG2-like-2; FSHD region gene 2 family member C | 0.554 |
| LMTK3 | HERC1 | ENSP00000270238 | ENSP00000390158 | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | Probable E3 ubiquitin-protein ligase HERC1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; WD repeat domain containing | 0.461 |
| LMTK3 | HOOK2 | ENSP00000270238 | ENSP00000380785 | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity); Protein phosphatase 1 regulatory subunits | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones | 0.703 |
