| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EMP3 | FAM83E | ENSP00000270221 | ENSP00000263266 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Protein FAM83E; May play a role in MAPK signaling | 0.657 |
| EMP3 | FUT1 | ENSP00000270221 | ENSP00000312021 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | 0.647 |
| EMP3 | GFI1B | ENSP00000270221 | ENSP00000344782 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] | 0.641 |
| EMP3 | GSN | ENSP00000270221 | ENSP00000362924 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis; Gelsolin/villins | 0.655 |
| EMP3 | GTF3C5 | ENSP00000270221 | ENSP00000361180 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | 0.685 |
| EMP3 | GUCA1B | ENSP00000270221 | ENSP00000230361 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Guanylyl cyclase-activating protein 2; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing | 0.661 |
| EMP3 | LGALS1 | ENSP00000270221 | ENSP00000215909 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis; Endogenous ligands | 0.694 |
| EMP3 | MAPK8IP1 | ENSP00000270221 | ENSP00000241014 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. [...] | 0.623 |
| EMP3 | NELL1 | ENSP00000270221 | ENSP00000298925 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.657 |
| EMP3 | ZNF362 | ENSP00000270221 | ENSP00000446335 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Zinc finger protein 362; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.616 |
| FAM83E | EMP3 | ENSP00000263266 | ENSP00000270221 | Protein FAM83E; May play a role in MAPK signaling | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | 0.657 |
| FAM83E | FUT1 | ENSP00000263266 | ENSP00000312021 | Protein FAM83E; May play a role in MAPK signaling | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | 0.624 |
| FAM83E | GFI1B | ENSP00000263266 | ENSP00000344782 | Protein FAM83E; May play a role in MAPK signaling | Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] | 0.437 |
| FAM83E | GTF3C5 | ENSP00000263266 | ENSP00000361180 | Protein FAM83E; May play a role in MAPK signaling | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | 0.694 |
| FAM83E | GUCA1B | ENSP00000263266 | ENSP00000230361 | Protein FAM83E; May play a role in MAPK signaling | Guanylyl cyclase-activating protein 2; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing | 0.642 |
| FAM83E | MAPK8IP1 | ENSP00000263266 | ENSP00000241014 | Protein FAM83E; May play a role in MAPK signaling | C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. [...] | 0.595 |
| FAM83E | NELL1 | ENSP00000263266 | ENSP00000298925 | Protein FAM83E; May play a role in MAPK signaling | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.554 |
| FAM83E | ZNF362 | ENSP00000263266 | ENSP00000446335 | Protein FAM83E; May play a role in MAPK signaling | Zinc finger protein 362; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.687 |
| FUT1 | EMP3 | ENSP00000312021 | ENSP00000270221 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | 0.647 |
| FUT1 | FAM83E | ENSP00000312021 | ENSP00000263266 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | Protein FAM83E; May play a role in MAPK signaling | 0.624 |
