node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHLHA9 | LRRC56 | ENSP00000375248 | ENSP00000270115 | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis; Basic helix-loop-helix proteins | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.732 |
BHLHA9 | SFMBT1 | ENSP00000375248 | ENSP00000378235 | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis; Basic helix-loop-helix proteins | Scm-like with four MBT domains protein 1; Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis- required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis; [...] | 0.678 |
DAW1 | LRRC56 | ENSP00000311899 | ENSP00000270115 | Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.669 |
DUSP8 | LRRC56 | ENSP00000380530 | ENSP00000270115 | Dual specificity protein phosphatase 8; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.598 |
DUSP8 | PKP3 | ENSP00000380530 | ENSP00000331678 | Dual specificity protein phosphatase 8; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Plakophilin-3; May play a role in junctional plaques; Armadillo repeat containing | 0.423 |
ELFN2 | LRRC46 | ENSP00000385277 | ENSP00000269025 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.587 |
ELFN2 | LRRC56 | ENSP00000385277 | ENSP00000270115 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.574 |
LPHN1 | LRRC46 | ENSP00000340688 | ENSP00000269025 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
LPHN1 | LRRC56 | ENSP00000340688 | ENSP00000270115 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.683 |
LPHN2 | LRRC46 | ENSP00000322270 | ENSP00000269025 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
LPHN2 | LRRC56 | ENSP00000322270 | ENSP00000270115 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.683 |
LPHN3 | LRRC46 | ENSP00000422533 | ENSP00000269025 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
LPHN3 | LRRC56 | ENSP00000422533 | ENSP00000270115 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.683 |
LRRC46 | ELFN2 | ENSP00000269025 | ENSP00000385277 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | 0.587 |
LRRC46 | LPHN1 | ENSP00000269025 | ENSP00000340688 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.683 |
LRRC46 | LPHN2 | ENSP00000269025 | ENSP00000322270 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.683 |
LRRC46 | LPHN3 | ENSP00000269025 | ENSP00000422533 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.683 |
LRRC46 | LRRC56 | ENSP00000269025 | ENSP00000270115 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.611 |
LRRC56 | BHLHA9 | ENSP00000270115 | ENSP00000375248 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis; Basic helix-loop-helix proteins | 0.732 |
LRRC56 | DAW1 | ENSP00000270115 | ENSP00000311899 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family | 0.669 |