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  • 11.0 [archived version]
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BHLHA9 BHLHA9 SFMBT1 SFMBT1 DAW1 DAW1 LRRC56 LRRC56 LPHN3 LPHN3 DUSP8 DUSP8 ELFN2 ELFN2 LRRC46 LRRC46 PKP3 PKP3 LPHN1 LPHN1 LPHN2 LPHN2
"LRRC56" - Leucine-rich repeat-containing protein 56 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
LRRC56Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 (542 aa)    
Predicted Functional Partners:
BHLHA9
Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis; Basic helix-loop-helix proteins (235 aa)
           
  0.732
PKP3
Plakophilin-3; May play a role in junctional plaques; Armadillo repeat containing (797 aa)
     
 
  0.709
LPHN3
Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily (1469 aa)
       
      0.683
LPHN1
Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) (1474 aa)
       
      0.683
LPHN2
Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily (1403 aa)
       
      0.683
DAW1
Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family (415 aa)
     
 
  0.669
SFMBT1
Scm-like with four MBT domains protein 1; Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis- required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis; [...] (866 aa)
     
   
  0.663
LRRC46
Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 (321 aa)
     
   
  0.611
DUSP8
Dual specificity protein phosphatase 8; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily (625 aa)
       
 
  0.598
ELFN2
Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing (820 aa)
           
  0.574
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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