• Version:
  • 11.0 [archived version]
STRINGSTRING
ZNF488 ZNF488 EFCAB5 EFCAB5 PRDM8 PRDM8 SMIM15 SMIM15 SYS1 SYS1 PRDM15 PRDM15 HIST1H1A HIST1H1A C2CD2 C2CD2 PRR11 PRR11 ZBTB21 ZBTB21 RIPK4 RIPK4
"PRDM15" - PR domain zinc finger protein 15 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRDM15PR domain zinc finger protein 15; May be involved in transcriptional regulation; PR/SET domain family (1507 aa)    
Predicted Functional Partners:
SMIM15
Small integral membrane protein 15 (74 aa)
            
  0.767
PRDM8
PR domain zinc finger protein 8; Probable histone methyltransferase, preferentially acting on ’Lys-9’ of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity); Belongs to the class V-like SAM-binding methyltrans [...] (689 aa)
        
 
  0.690
EFCAB5
EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 (1503 aa)
            
  0.581
C2CD2
C2 calcium dependent domain containing 2 (696 aa)
            
  0.558
SYS1
Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family (156 aa)
            
  0.544
ZNF488
Zinc finger protein 488; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (340 aa)
            
  0.544
RIPK4
Receptor-interacting serine/threonine-protein kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family (784 aa)
      
 
  0.539
HIST1H1A
Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity) (215 aa)
        
      0.524
PRR11
Proline-rich protein 11; Plays a critical role in cell cycle progression (360 aa)
        
      0.517
ZBTB21
Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing (1066 aa)
            
  0.515
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >