node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR10 | DHPS | ENSP00000254286 | ENSP00000210060 | Actin related protein 10 homolog; Belongs to the actin family | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue | 0.532 |
ACTR10 | EPB42 | ENSP00000254286 | ENSP00000300215 | Actin related protein 10 homolog; Belongs to the actin family | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family | 0.557 |
ACTR10 | FARSA | ENSP00000254286 | ENSP00000320309 | Actin related protein 10 homolog; Belongs to the actin family | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | 0.633 |
ACTR10 | MIR1199 | ENSP00000254286 | ENSP00000269720 | Actin related protein 10 homolog; Belongs to the actin family | Uncharacterized protein MISP3; microRNA 1199; Belongs to the MISP family | 0.626 |
ACTR10 | UBR1 | ENSP00000254286 | ENSP00000290650 | Actin related protein 10 homolog; Belongs to the actin family | E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth; Belongs to the UBR1 family | 0.546 |
AKAP2 | MIR1199 | ENSP00000404782 | ENSP00000269720 | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity); A-kinase anchoring proteins | Uncharacterized protein MISP3; microRNA 1199; Belongs to the MISP family | 0.583 |
AKAP2 | PRKACA | ENSP00000404782 | ENSP00000309591 | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity); A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.450 |
DHPS | ACTR10 | ENSP00000210060 | ENSP00000254286 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue | Actin related protein 10 homolog; Belongs to the actin family | 0.532 |
DHPS | FARSA | ENSP00000210060 | ENSP00000320309 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | 0.697 |
DHPS | MIR1199 | ENSP00000210060 | ENSP00000269720 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue | Uncharacterized protein MISP3; microRNA 1199; Belongs to the MISP family | 0.513 |
DHPS | UBR1 | ENSP00000210060 | ENSP00000290650 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue | E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth; Belongs to the UBR1 family | 0.403 |
EPB42 | ACTR10 | ENSP00000300215 | ENSP00000254286 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family | Actin related protein 10 homolog; Belongs to the actin family | 0.557 |
EPB42 | FARSA | ENSP00000300215 | ENSP00000320309 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | 0.539 |
EPB42 | MIR1199 | ENSP00000300215 | ENSP00000269720 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family | Uncharacterized protein MISP3; microRNA 1199; Belongs to the MISP family | 0.539 |
EPB42 | UBR1 | ENSP00000300215 | ENSP00000290650 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family | E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth; Belongs to the UBR1 family | 0.505 |
FARSA | ACTR10 | ENSP00000320309 | ENSP00000254286 | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | Actin related protein 10 homolog; Belongs to the actin family | 0.633 |
FARSA | DHPS | ENSP00000320309 | ENSP00000210060 | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue | 0.697 |
FARSA | EPB42 | ENSP00000320309 | ENSP00000300215 | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family | 0.539 |
FARSA | MIR1199 | ENSP00000320309 | ENSP00000269720 | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | Uncharacterized protein MISP3; microRNA 1199; Belongs to the MISP family | 0.626 |
FARSA | UBR1 | ENSP00000320309 | ENSP00000290650 | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II | E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth; Belongs to the UBR1 family | 0.536 |