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  • 11.0 [archived version]
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ENSG00000274102 ENSG00000274102 ENSG00000182974 ENSG00000182974 ENSG00000271786 ENSG00000271786 CUBN CUBN CACNB2 CACNB2 ARL5C ARL5C SPEN SPEN NSUN6 NSUN6 VWA5B1 VWA5B1 OR5D13 OR5D13 ARL9 ARL9
"ARL5C" - Putative ADP-ribosylation factor-like protein 5C in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ARL5CPutative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP; ARF GTPase family (179 aa)    
Predicted Functional Partners:
ARL9
ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family (123 aa)
           
  0.716
VWA5B1
Von Willebrand factor A domain containing 5B1 (1220 aa)
           
  0.698
OR5D13
Olfactory receptor 5D13; Odorant receptor; Olfactory receptors, family 5 (314 aa)
           
  0.670
ENSG00000274102
Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 (313 aa)
           
  0.582
ENSG00000182974
Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 (313 aa)
           
  0.581
SPEN
Msx2-interacting protein; May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation- synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses t [...] (3664 aa)
       
 
  0.549
ENSG00000271786
Uncharacterized protein (91 aa)
           
  0.529
NSUN6
Putative methyltransferase NSUN6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity; NOP2/Sun RNA methyltransferase family (469 aa)
           
  0.529
CACNB2
Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting (660 aa)
           
  0.524
CUBN
Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. [...] (3623 aa)
           
  0.523
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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