• Version:
  • 11.0 [archived version]
STRINGSTRING
GTPBP4 GTPBP4 UTP15 UTP15 DDX6 DDX6 FBXO16 FBXO16 PHACTR2 PHACTR2 ZCCHC2 ZCCHC2 C11orf57 C11orf57 KIAA1468 KIAA1468 USP38 USP38 CMTR1 CMTR1 LYSMD2 LYSMD2
"ZCCHC2" - Zinc finger CCHC-type containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZCCHC2Zinc finger CCHC-type containing 2 (1178 aa)    
Predicted Functional Partners:
CMTR1
Cap-specific mRNA (nucleoside-2’-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2’-O-ribose methylation to the 5’-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway; G-patch domain containing (835 aa)
           
  0.682
DDX6
Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily (483 aa)
     
 
  0.592
LYSMD2
LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 (215 aa)
           
  0.582
UTP15
U3 small nucleolar RNA-associated protein 15 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I; UTPa subcomplex (518 aa)
     
        0.582
KIAA1468
LisH domain and HEAT repeat-containing protein KIAA1468; Armadillo-like helical domain containing (1216 aa)
           
  0.570
FBXO16
F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other (292 aa)
     
   
  0.556
USP38
Ubiquitin carboxyl-terminal hydrolase 38; Deubiquitinating enzyme exhibiting a preference towards ’Lys-63’-linked ubiquitin chains; Belongs to the peptidase C19 family (1042 aa)
     
   
  0.555
GTPBP4
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily (634 aa)
     
 
  0.552
PHACTR2
Phosphatase and actin regulator 2 (645 aa)
     
   
  0.549
C11orf57
Uncharacterized protein NKAPD1; Chromosome 11 open reading frame 57 (293 aa)
           
  0.546
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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