node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC68 | ELAC1 | ENSP00000466690 | ENSP00000269466 | Coiled-coil domain-containing protein 68; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | 0.722 |
CCDC68 | STARD6 | ENSP00000466690 | ENSP00000462349 | Coiled-coil domain-containing protein 68; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly | StAR-related lipid transfer protein 6; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity); StAR related lipid transfer domain containing | 0.645 |
ELAC1 | CCDC68 | ENSP00000269466 | ENSP00000466690 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | Coiled-coil domain-containing protein 68; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly | 0.722 |
ELAC1 | ELAC2 | ENSP00000269466 | ENSP00000337445 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | 0.862 |
ELAC1 | NOC2L | ENSP00000269466 | ENSP00000317992 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing | 0.702 |
ELAC1 | NOP14 | ENSP00000269466 | ENSP00000405068 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity); Belongs to the NOP14 family | 0.719 |
ELAC1 | POLR1B | ENSP00000269466 | ENSP00000444136 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.684 |
ELAC1 | RAB3D | ENSP00000269466 | ENSP00000222120 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | Ras-related protein Rab-3D; Protein transport. Probably involved in regulated exocytosis (By similarity); Belongs to the small GTPase superfamily. Rab family | 0.773 |
ELAC1 | RRP12 | ENSP00000269466 | ENSP00000446184 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | RRP12-like protein; Armadillo-like helical domain containing | 0.737 |
ELAC1 | STARD6 | ENSP00000269466 | ENSP00000462349 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | StAR-related lipid transfer protein 6; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity); StAR related lipid transfer domain containing | 0.713 |
ELAC1 | TBL3 | ENSP00000269466 | ENSP00000454836 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | Transducin beta-like protein 3; WD repeat domain containing; UTPb subcomplex | 0.754 |
ELAC1 | WDR36 | ENSP00000269466 | ENSP00000423067 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex | 0.703 |
ELAC2 | ELAC1 | ENSP00000337445 | ENSP00000269466 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | 0.862 |
ELAC2 | NOC2L | ENSP00000337445 | ENSP00000317992 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing | 0.835 |
ELAC2 | NOP14 | ENSP00000337445 | ENSP00000405068 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity); Belongs to the NOP14 family | 0.832 |
ELAC2 | POLR1B | ENSP00000337445 | ENSP00000444136 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.684 |
ELAC2 | RRP12 | ENSP00000337445 | ENSP00000446184 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | RRP12-like protein; Armadillo-like helical domain containing | 0.889 |
ELAC2 | TBL3 | ENSP00000337445 | ENSP00000454836 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | Transducin beta-like protein 3; WD repeat domain containing; UTPb subcomplex | 0.861 |
ELAC2 | WDR36 | ENSP00000337445 | ENSP00000423067 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3’-processing endonuclease activity. Involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA | WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex | 0.821 |
NOC2L | ELAC1 | ENSP00000317992 | ENSP00000269466 | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family | 0.702 |