| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APBB1 | RNF157 | ENSP00000477213 | ENSP00000269391 | Amyloid-beta A4 precursor protein-binding family B member 1; Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on ’Tyr-142’ (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro- apoptosis factors such as MAPK8/JNK [...] | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins | 0.562 |
| ATRN | RNF157 | ENSP00000262919 | ENSP00000269391 | Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity); C-type lectin domain containing | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins | 0.558 |
| CDH12 | KIAA1211 | ENSP00000371689 | ENSP00000423366 | Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | Uncharacterized protein KIAA1211; KIAA1211 | 0.609 |
| CDH12 | MEF2BNB | ENSP00000371689 | ENSP00000425864 | Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | 0.595 |
| CDH12 | PRPSAP1 | ENSP00000371689 | ENSP00000414624 | Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.502 |
| CDH12 | RNF157 | ENSP00000371689 | ENSP00000269391 | Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins | 0.610 |
| CDH12 | TM6SF2 | ENSP00000371689 | ENSP00000374014 | Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase; Belongs to the TM6SF family | 0.592 |
| GPR61 | KIAA1211 | ENSP00000432456 | ENSP00000423366 | Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Uncharacterized protein KIAA1211; KIAA1211 | 0.686 |
| GPR61 | MEF2BNB | ENSP00000432456 | ENSP00000425864 | Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | 0.712 |
| GPR61 | PRPSAP1 | ENSP00000432456 | ENSP00000414624 | Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.680 |
| GPR61 | RNF157 | ENSP00000432456 | ENSP00000269391 | Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins | 0.687 |
| GPR61 | TM6SF2 | ENSP00000432456 | ENSP00000374014 | Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase; Belongs to the TM6SF family | 0.527 |
| GPRC5C | OTOP3 | ENSP00000376403 | ENSP00000328090 | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways; G protein-coupled receptors, Class C orphans | Otopetrin-3; Otopetrin 3 | 0.504 |
| GPRC5C | RNF157 | ENSP00000376403 | ENSP00000269391 | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways; G protein-coupled receptors, Class C orphans | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins | 0.555 |
| KIAA1211 | CDH12 | ENSP00000423366 | ENSP00000371689 | Uncharacterized protein KIAA1211; KIAA1211 | Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.609 |
| KIAA1211 | GPR61 | ENSP00000423366 | ENSP00000432456 | Uncharacterized protein KIAA1211; KIAA1211 | Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | 0.686 |
| KIAA1211 | MEF2BNB | ENSP00000423366 | ENSP00000425864 | Uncharacterized protein KIAA1211; KIAA1211 | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | 0.722 |
| KIAA1211 | PRPSAP1 | ENSP00000423366 | ENSP00000414624 | Uncharacterized protein KIAA1211; KIAA1211 | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.697 |
| KIAA1211 | RNF157 | ENSP00000423366 | ENSP00000269391 | Uncharacterized protein KIAA1211; KIAA1211 | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins | 0.706 |
| KIAA1211 | TM6SF2 | ENSP00000423366 | ENSP00000374014 | Uncharacterized protein KIAA1211; KIAA1211 | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase; Belongs to the TM6SF family | 0.647 |
