| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BPTF | FBXL19 | ENSP00000307208 | ENSP00000369666 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.408 |
| BPTF | ZMYND15 | ENSP00000307208 | ENSP00000269289 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.473 |
| FBXL19 | BPTF | ENSP00000369666 | ENSP00000307208 | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | 0.408 |
| FBXL19 | ZMYND15 | ENSP00000369666 | ENSP00000269289 | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.499 |
| GAPT | ZMYND15 | ENSP00000379997 | ENSP00000269289 | Protein GAPT; Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity); Belongs to the GAPT family | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.468 |
| GPR155 | ZMYND15 | ENSP00000376335 | ENSP00000269289 | Integral membrane protein GPR155; G protein-coupled receptor 155 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.420 |
| KDM7A | ZMYND15 | ENSP00000380692 | ENSP00000269289 | Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4 [...] | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.429 |
| SECTM1 | ZMYND15 | ENSP00000269389 | ENSP00000269289 | Secreted and transmembrane protein 1; May be involved in thymocyte signaling | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.508 |
| SPEM1 | TNP1 | ENSP00000315554 | ENSP00000236979 | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction; Belongs to the nuclear transition protein 1 family | 0.689 |
| SPEM1 | ZMYND15 | ENSP00000315554 | ENSP00000269289 | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.650 |
| TEX11 | ZMYND15 | ENSP00000379226 | ENSP00000269289 | Testis-expressed protein 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.484 |
| TNP1 | SPEM1 | ENSP00000236979 | ENSP00000315554 | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction; Belongs to the nuclear transition protein 1 family | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis | 0.689 |
| TNP1 | ZMYND15 | ENSP00000236979 | ENSP00000269289 | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction; Belongs to the nuclear transition protein 1 family | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.476 |
| ZMYND12 | ZMYND15 | ENSP00000361646 | ENSP00000269289 | Zinc finger MYND-type containing 12 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | 0.656 |
| ZMYND15 | BPTF | ENSP00000269289 | ENSP00000307208 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | 0.473 |
| ZMYND15 | FBXL19 | ENSP00000269289 | ENSP00000369666 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.499 |
| ZMYND15 | GAPT | ENSP00000269289 | ENSP00000379997 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | Protein GAPT; Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity); Belongs to the GAPT family | 0.468 |
| ZMYND15 | GPR155 | ENSP00000269289 | ENSP00000376335 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | Integral membrane protein GPR155; G protein-coupled receptor 155 | 0.420 |
| ZMYND15 | KDM7A | ENSP00000269289 | ENSP00000380692 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4 [...] | 0.429 |
| ZMYND15 | SECTM1 | ENSP00000269289 | ENSP00000269389 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type | Secreted and transmembrane protein 1; May be involved in thymocyte signaling | 0.508 |
