| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF5 | GAREM | ENSP00000056217 | ENSP00000269209 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.525 |
| ASXL3 | C18orf21 | ENSP00000269197 | ENSP00000465517 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | 0.442 |
| ASXL3 | GAREM | ENSP00000269197 | ENSP00000269209 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.523 |
| C18orf21 | ASXL3 | ENSP00000465517 | ENSP00000269197 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | 0.442 |
| C18orf21 | CCDC178 | ENSP00000465517 | ENSP00000372576 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | Coiled-coil domain containing 178 | 0.588 |
| C18orf21 | GAREM | ENSP00000465517 | ENSP00000269209 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.548 |
| CCDC178 | C18orf21 | ENSP00000372576 | ENSP00000465517 | Coiled-coil domain containing 178 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | 0.588 |
| CCDC178 | GAREM | ENSP00000372576 | ENSP00000269209 | Coiled-coil domain containing 178 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.581 |
| EFNA1 | GAREM | ENSP00000357392 | ENSP00000269209 | Ephrin-A1; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration a [...] | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.691 |
| EFNA1 | GRB2 | ENSP00000357392 | ENSP00000376345 | Ephrin-A1; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration a [...] | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing | 0.922 |
| FAM154A | GAREM | ENSP00000369907 | ENSP00000269209 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.587 |
| FAM196A | GAREM | ENSP00000429763 | ENSP00000269209 | Protein FAM196A; Family with sequence similarity 196 member A | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.539 |
| GAREM | ARHGEF5 | ENSP00000269209 | ENSP00000056217 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | 0.525 |
| GAREM | ASXL3 | ENSP00000269209 | ENSP00000269197 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | 0.523 |
| GAREM | C18orf21 | ENSP00000269209 | ENSP00000465517 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | 0.548 |
| GAREM | CCDC178 | ENSP00000269209 | ENSP00000372576 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Coiled-coil domain containing 178 | 0.581 |
| GAREM | EFNA1 | ENSP00000269209 | ENSP00000357392 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Ephrin-A1; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration a [...] | 0.691 |
| GAREM | FAM154A | ENSP00000269209 | ENSP00000369907 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.587 |
| GAREM | FAM196A | ENSP00000269209 | ENSP00000429763 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Protein FAM196A; Family with sequence similarity 196 member A | 0.539 |
| GAREM | GRB2 | ENSP00000269209 | ENSP00000376345 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing | 0.692 |
