| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AADAT | SPACA3 | ENSP00000423190 | ENSP00000269053 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.689 |
| ACRV1 | SPACA1 | ENSP00000432816 | ENSP00000237201 | Acrosomal vesicle protein 1 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | 0.827 |
| ACRV1 | SPACA3 | ENSP00000432816 | ENSP00000269053 | Acrosomal vesicle protein 1 | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.629 |
| ACRV1 | SPACA4 | ENSP00000432816 | ENSP00000312774 | Acrosomal vesicle protein 1 | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing | 0.717 |
| ASTL | FETUB | ENSP00000343674 | ENSP00000265029 | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity); Belongs to the peptidase M12A family | Fetuin-B; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity); Belongs to the fetuin family | 0.666 |
| ASTL | SPACA3 | ENSP00000343674 | ENSP00000269053 | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity); Belongs to the peptidase M12A family | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.603 |
| CCDC110 | SPACA3 | ENSP00000306776 | ENSP00000269053 | Coiled-coil domain containing 110 | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.573 |
| CCDC110 | ZNF165 | ENSP00000306776 | ENSP00000366542 | Coiled-coil domain containing 110 | Zinc finger protein 165; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.671 |
| FETUB | ASTL | ENSP00000265029 | ENSP00000343674 | Fetuin-B; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity); Belongs to the fetuin family | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity); Belongs to the peptidase M12A family | 0.666 |
| FETUB | SPACA3 | ENSP00000265029 | ENSP00000269053 | Fetuin-B; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity); Belongs to the fetuin family | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.554 |
| HSPB3 | SPACA3 | ENSP00000303394 | ENSP00000269053 | Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.539 |
| IZUMO4 | SPACA1 | ENSP00000378712 | ENSP00000237201 | Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | 0.475 |
| IZUMO4 | SPACA3 | ENSP00000378712 | ENSP00000269053 | Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.515 |
| SPACA1 | ACRV1 | ENSP00000237201 | ENSP00000432816 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | Acrosomal vesicle protein 1 | 0.827 |
| SPACA1 | IZUMO4 | ENSP00000237201 | ENSP00000378712 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family | 0.475 |
| SPACA1 | SPACA3 | ENSP00000237201 | ENSP00000269053 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.660 |
| SPACA1 | SPACA4 | ENSP00000237201 | ENSP00000312774 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing | 0.786 |
| SPACA3 | AADAT | ENSP00000269053 | ENSP00000423190 | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) | 0.689 |
| SPACA3 | ACRV1 | ENSP00000269053 | ENSP00000432816 | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | Acrosomal vesicle protein 1 | 0.629 |
| SPACA3 | ASTL | ENSP00000269053 | ENSP00000343674 | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity); Belongs to the peptidase M12A family | 0.603 |
