node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR111 | LRRC46 | ENSP00000296862 | ENSP00000269025 | Adhesion G-protein coupled receptor F2; Orphan receptor | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.822 |
GPR111 | MCCD1 | ENSP00000296862 | ENSP00000365362 | Adhesion G-protein coupled receptor F2; Orphan receptor | Mitochondrial coiled-coil domain 1 | 0.657 |
LPHN1 | LRRC46 | ENSP00000340688 | ENSP00000269025 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
LPHN1 | LRRC69 | ENSP00000340688 | ENSP00000400803 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.685 |
LPHN2 | LRRC46 | ENSP00000322270 | ENSP00000269025 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
LPHN2 | LRRC69 | ENSP00000322270 | ENSP00000400803 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.685 |
LPHN3 | LRRC46 | ENSP00000422533 | ENSP00000269025 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
LPHN3 | LRRC69 | ENSP00000422533 | ENSP00000400803 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.685 |
LRRC46 | GPR111 | ENSP00000269025 | ENSP00000296862 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G-protein coupled receptor F2; Orphan receptor | 0.822 |
LRRC46 | LPHN1 | ENSP00000269025 | ENSP00000340688 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.683 |
LRRC46 | LPHN2 | ENSP00000269025 | ENSP00000322270 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.683 |
LRRC46 | LPHN3 | ENSP00000269025 | ENSP00000422533 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.683 |
LRRC46 | LRRC69 | ENSP00000269025 | ENSP00000400803 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.658 |
LRRC46 | MCCD1 | ENSP00000269025 | ENSP00000365362 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Mitochondrial coiled-coil domain 1 | 0.682 |
LRRC46 | MYO1G | ENSP00000269025 | ENSP00000258787 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent proce [...] | 0.630 |
LRRC46 | PACS2 | ENSP00000269025 | ENSP00000393559 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct [...] | 0.808 |
LRRC46 | POLE | ENSP00000269025 | ENSP00000322570 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | DNA polymerase epsilon catalytic subunit A; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase type-B family | 0.622 |
LRRC46 | QSOX2 | ENSP00000269025 | ENSP00000351536 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Sulfhydryl oxidase 2; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis | 0.687 |
LRRC69 | LPHN1 | ENSP00000400803 | ENSP00000340688 | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.685 |
LRRC69 | LPHN2 | ENSP00000400803 | ENSP00000322270 | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.685 |