node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC8 | COPE | ENSP00000420333 | ENSP00000262812 | Armadillo repeat containing 8 | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex [...] | 0.508 |
ARMC8 | GID4 | ENSP00000420333 | ENSP00000268719 | Armadillo repeat containing 8 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | 0.914 |
ARMC8 | GID8 | ENSP00000420333 | ENSP00000266069 | Armadillo repeat containing 8 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.968 |
ARMC8 | MAEA | ENSP00000420333 | ENSP00000302830 | Armadillo repeat containing 8 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 0.897 |
ARMC8 | MKLN1 | ENSP00000420333 | ENSP00000323527 | Armadillo repeat containing 8 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.796 |
ARMC8 | RANBP9 | ENSP00000420333 | ENSP00000011619 | Armadillo repeat containing 8 | Ran-binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.895 |
ARMC8 | RMND5A | ENSP00000420333 | ENSP00000283632 | Armadillo repeat containing 8 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.964 |
ARMC8 | RMND5B | ENSP00000420333 | ENSP00000420875 | Armadillo repeat containing 8 | Protein RMD5 homolog B; Required for meiotic nuclear division 5 homolog B | 0.849 |
ARMC8 | WDR26 | ENSP00000420333 | ENSP00000408108 | Armadillo repeat containing 8 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.961 |
COPE | ARMC8 | ENSP00000262812 | ENSP00000420333 | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex [...] | Armadillo repeat containing 8 | 0.508 |
COPE | GID4 | ENSP00000262812 | ENSP00000268719 | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex [...] | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | 0.711 |
FAM219A | GID4 | ENSP00000392452 | ENSP00000268719 | Protein FAM219A; Family with sequence similarity 219 member A | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | 0.701 |
GID4 | ARMC8 | ENSP00000268719 | ENSP00000420333 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Armadillo repeat containing 8 | 0.914 |
GID4 | COPE | ENSP00000268719 | ENSP00000262812 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex [...] | 0.711 |
GID4 | FAM219A | ENSP00000268719 | ENSP00000392452 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Protein FAM219A; Family with sequence similarity 219 member A | 0.701 |
GID4 | GID8 | ENSP00000268719 | ENSP00000266069 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.933 |
GID4 | MAEA | ENSP00000268719 | ENSP00000302830 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 0.855 |
GID4 | MKLN1 | ENSP00000268719 | ENSP00000323527 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.717 |
GID4 | RANBP9 | ENSP00000268719 | ENSP00000011619 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Ran-binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.828 |
GID4 | RMND5A | ENSP00000268719 | ENSP00000283632 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.971 |