node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP7 | DEF8 | ENSP00000405252 | ENSP00000268676 | A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium; A-kinase anchoring proteins | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | 0.553 |
AKAP7 | FBXL4 | ENSP00000405252 | ENSP00000358247 | A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium; A-kinase anchoring proteins | F-box and leucine rich repeat protein 4 | 0.499 |
DBNDD1 | DEF8 | ENSP00000457625 | ENSP00000268676 | Dysbindin domain containing 1 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | 0.661 |
DBNDD1 | SPATA2L | ENSP00000457625 | ENSP00000289805 | Dysbindin domain containing 1 | Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like | 0.601 |
DBNDD1 | SPATA33 | ENSP00000457625 | ENSP00000462996 | Dysbindin domain containing 1 | Spermatogenesis-associated protein 33; Spermatogenesis associated 33 | 0.617 |
DBNDD1 | SPIRE2 | ENSP00000457625 | ENSP00000367494 | Dysbindin domain containing 1 | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis | 0.601 |
DBNDD1 | TCF25 | ENSP00000457625 | ENSP00000263346 | Dysbindin domain containing 1 | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development; Belongs to the TCF25 family | 0.814 |
DEF8 | AKAP7 | ENSP00000268676 | ENSP00000405252 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium; A-kinase anchoring proteins | 0.553 |
DEF8 | DBNDD1 | ENSP00000268676 | ENSP00000457625 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | Dysbindin domain containing 1 | 0.661 |
DEF8 | FAM98A | ENSP00000268676 | ENSP00000238823 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | Protein FAM98A; Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy; tRNA splicing ligase complex | 0.596 |
DEF8 | FBXL4 | ENSP00000268676 | ENSP00000358247 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | F-box and leucine rich repeat protein 4 | 0.571 |
DEF8 | PLEKHM3 | ENSP00000268676 | ENSP00000417003 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | Pleckstrin homology domain containing M3 | 0.649 |
DEF8 | SPATA2L | ENSP00000268676 | ENSP00000289805 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like | 0.586 |
DEF8 | SPATA33 | ENSP00000268676 | ENSP00000462996 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | Spermatogenesis-associated protein 33; Spermatogenesis associated 33 | 0.662 |
DEF8 | SPIRE2 | ENSP00000268676 | ENSP00000367494 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis | 0.609 |
DEF8 | TCF25 | ENSP00000268676 | ENSP00000263346 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development; Belongs to the TCF25 family | 0.600 |
DEF8 | WDR25 | ENSP00000268676 | ENSP00000334148 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | WD repeat-containing protein 25; WD repeat domain containing | 0.621 |
FAM98A | DEF8 | ENSP00000238823 | ENSP00000268676 | Protein FAM98A; Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy; tRNA splicing ligase complex | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | 0.596 |
FBXL4 | AKAP7 | ENSP00000358247 | ENSP00000405252 | F-box and leucine rich repeat protein 4 | A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium; A-kinase anchoring proteins | 0.499 |
FBXL4 | DEF8 | ENSP00000358247 | ENSP00000268676 | F-box and leucine rich repeat protein 4 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption | 0.571 |