• Version:
  • 11.0 [archived version]
STRINGSTRING
TCF25 TCF25 DBNDD1 DBNDD1 SPIRE2 SPIRE2 SPATA33 SPATA33 SPATA2L SPATA2L FAM98A FAM98A DEF8 DEF8 PLEKHM3 PLEKHM3 AKAP7 AKAP7 FBXL4 FBXL4 WDR25 WDR25
"DEF8" - Differentially expressed in FDCP 8 homolog in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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DEF8Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption (512 aa)    
Predicted Functional Partners:
SPATA33
Spermatogenesis-associated protein 33; Spermatogenesis associated 33 (140 aa)
           
  0.662
DBNDD1
Dysbindin domain containing 1 (278 aa)
           
  0.661
PLEKHM3
Pleckstrin homology domain containing M3 (761 aa)
       
   
0.649
WDR25
WD repeat-containing protein 25; WD repeat domain containing (544 aa)
           
  0.621
SPIRE2
Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (714 aa)
           
  0.609
TCF25
Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development; Belongs to the TCF25 family (676 aa)
           
  0.600
FAM98A
Protein FAM98A; Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy; tRNA splicing ligase complex (518 aa)
           
  0.596
SPATA2L
Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like (424 aa)
           
  0.586
FBXL4
F-box and leucine rich repeat protein 4 (621 aa)
     
   
  0.571
AKAP7
A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium; A-kinase anchoring proteins (348 aa)
           
  0.553
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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