node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRSK1 | CDR2 | ENSP00000310649 | ENSP00000268383 | Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE [...] | Cerebellar degeneration related protein 2 | 0.712 |
CDR1 | CDR2 | ENSP00000359563 | ENSP00000268383 | Cerebellar degeneration related protein 1 | Cerebellar degeneration related protein 2 | 0.930 |
CDR1 | DUSP5 | ENSP00000359563 | ENSP00000358596 | Cerebellar degeneration related protein 1 | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1; MAP kinase phosphatases | 0.587 |
CDR1 | IGHV4-38-2 | ENSP00000359563 | ENSP00000478289 | Cerebellar degeneration related protein 1 | Immunoglobulin heavy variable 4-38-2; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | 0.646 |
CDR2 | BRSK1 | ENSP00000268383 | ENSP00000310649 | Cerebellar degeneration related protein 2 | Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE [...] | 0.712 |
CDR2 | CDR1 | ENSP00000268383 | ENSP00000359563 | Cerebellar degeneration related protein 2 | Cerebellar degeneration related protein 1 | 0.930 |
CDR2 | CDR2L | ENSP00000268383 | ENSP00000336587 | Cerebellar degeneration related protein 2 | Cerebellar degeneration related protein 2 like | 0.732 |
CDR2 | DUSP5 | ENSP00000268383 | ENSP00000358596 | Cerebellar degeneration related protein 2 | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1; MAP kinase phosphatases | 0.669 |
CDR2 | IGHV4-38-2 | ENSP00000268383 | ENSP00000478289 | Cerebellar degeneration related protein 2 | Immunoglobulin heavy variable 4-38-2; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | 0.669 |
CDR2 | IGSF3 | ENSP00000268383 | ENSP00000358495 | Cerebellar degeneration related protein 2 | Immunoglobulin superfamily member 3; Immunoglobulin like domain containing | 0.619 |
CDR2 | MYC | ENSP00000268383 | ENSP00000479618 | Cerebellar degeneration related protein 2 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’- CAC[GA]TG-3’. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis; Basic helix-loop-helix proteins | 0.749 |
CDR2 | NARS | ENSP00000268383 | ENSP00000256854 | Cerebellar degeneration related protein 2 | Asparagine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class II | 0.667 |
CDR2 | PKN1 | ENSP00000268383 | ENSP00000343325 | Cerebellar degeneration related protein 2 | Serine/threonine-protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates ’Ser-575’, ’Ser-637’ and ’Se [...] | 0.662 |
CDR2 | SSX3 | ENSP00000268383 | ENSP00000298396 | Cerebellar degeneration related protein 2 | Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family | 0.671 |
CDR2L | CDR2 | ENSP00000336587 | ENSP00000268383 | Cerebellar degeneration related protein 2 like | Cerebellar degeneration related protein 2 | 0.732 |
DUSP5 | CDR1 | ENSP00000358596 | ENSP00000359563 | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1; MAP kinase phosphatases | Cerebellar degeneration related protein 1 | 0.587 |
DUSP5 | CDR2 | ENSP00000358596 | ENSP00000268383 | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1; MAP kinase phosphatases | Cerebellar degeneration related protein 2 | 0.669 |
DUSP5 | IGHV4-38-2 | ENSP00000358596 | ENSP00000478289 | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1; MAP kinase phosphatases | Immunoglobulin heavy variable 4-38-2; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | 0.670 |
IGHV4-38-2 | CDR1 | ENSP00000478289 | ENSP00000359563 | Immunoglobulin heavy variable 4-38-2; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | Cerebellar degeneration related protein 1 | 0.646 |
IGHV4-38-2 | CDR2 | ENSP00000478289 | ENSP00000268383 | Immunoglobulin heavy variable 4-38-2; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whi [...] | Cerebellar degeneration related protein 2 | 0.669 |