| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOA1BP | ZNF710 | ENSP00000357218 | ENSP00000268154 | NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.477 |
| CAMK1G | ZNF710 | ENSP00000009105 | ENSP00000268154 | Calcium/calmodulin-dependent protein kinase type 1G; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.476 |
| MPPE1 | ZNF710 | ENSP00000465894 | ENSP00000268154 | Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins; Belongs to the metallophosphoesterase superfamily. MPPE1 family | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.513 |
| POLD1 | RPS6KL1 | ENSP00000406046 | ENSP00000346644 | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3’- to 5’-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | Ribosomal protein S6 kinase like 1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily | 0.709 |
| POLD1 | ZNF710 | ENSP00000406046 | ENSP00000268154 | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3’- to 5’-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.687 |
| RHBDL2 | ZNF710 | ENSP00000289248 | ENSP00000268154 | Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate- EFNB3; Rhomboid family | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.551 |
| RPS6KL1 | POLD1 | ENSP00000346644 | ENSP00000406046 | Ribosomal protein S6 kinase like 1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3’- to 5’-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | 0.709 |
| RPS6KL1 | ZNF710 | ENSP00000346644 | ENSP00000268154 | Ribosomal protein S6 kinase like 1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.840 |
| SPATS2 | ZNF710 | ENSP00000448228 | ENSP00000268154 | Spermatogenesis-associated serine-rich protein 2; Spermatogenesis associated serine rich 2 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.448 |
| TRIM28 | ZNF710 | ENSP00000253024 | ENSP00000268154 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.906 |
| TTC22 | ZNF710 | ENSP00000360323 | ENSP00000268154 | Tetratricopeptide repeat domain containing | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
| ZNF710 | APOA1BP | ENSP00000268154 | ENSP00000357218 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family | 0.477 |
| ZNF710 | CAMK1G | ENSP00000268154 | ENSP00000009105 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Calcium/calmodulin-dependent protein kinase type 1G; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily | 0.476 |
| ZNF710 | MPPE1 | ENSP00000268154 | ENSP00000465894 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins; Belongs to the metallophosphoesterase superfamily. MPPE1 family | 0.513 |
| ZNF710 | POLD1 | ENSP00000268154 | ENSP00000406046 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3’- to 5’-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | 0.687 |
| ZNF710 | RHBDL2 | ENSP00000268154 | ENSP00000289248 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate- EFNB3; Rhomboid family | 0.551 |
| ZNF710 | RPS6KL1 | ENSP00000268154 | ENSP00000346644 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ribosomal protein S6 kinase like 1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily | 0.840 |
| ZNF710 | SPATS2 | ENSP00000268154 | ENSP00000448228 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Spermatogenesis-associated serine-rich protein 2; Spermatogenesis associated serine rich 2 | 0.448 |
| ZNF710 | TRIM28 | ENSP00000268154 | ENSP00000253024 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.906 |
| ZNF710 | TTC22 | ENSP00000268154 | ENSP00000360323 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Tetratricopeptide repeat domain containing | 0.473 |
