• Version:
  • 11.0 [archived version]
STRINGSTRING
ADAMTSL3 ADAMTSL3 ADAMTS13 ADAMTS13 ADAMTSL2 ADAMTSL2 THSD4 THSD4 ADAMTSL4 ADAMTSL4 ADAMTSL1 ADAMTSL1 ADAMTS17 ADAMTS17 THBS1 THBS1 B3GALTL B3GALTL POFUT2 POFUT2 ADAMTSL5 ADAMTSL5
"ADAMTS17" - ADAM metallopeptidase with thrombospondin type 1 motif 17 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17 (1095 aa)    
Predicted Functional Partners:
POFUT2
GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and l [...] (429 aa)
     
 
  0.958
B3GALTL
Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (498 aa)
         
  0.955
ADAMTSL4
ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis; ADAMTS like (1097 aa)
         
0.931
ADAMTSL2
ADAMTS-like protein 2; ADAMTS like 2 (951 aa)
         
0.929
THBS1
Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity) (1170 aa)
         
0.925
THSD4
Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity); ADAMTS like (1018 aa)
         
0.925
ADAMTSL3
ADAMTS-like protein 3; Immunoglobulin like domain containing (1691 aa)
     
 
0.925
ADAMTSL1
ADAMTS-like protein 1; I-set domain containing; ADAMTS like (1762 aa)
     
 
0.923
ADAMTS13
A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif (1427 aa)
         
0.923
ADAMTSL5
ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like (471 aa)
         
0.919
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]