| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHH | DISP2 | ENSP00000266991 | ENSP00000267889 | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family | Dispatched RND transporter family member 2 | 0.957 |
| DHH | IHH | ENSP00000266991 | ENSP00000295731 | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family | Indian hedgehog protein; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity); Belongs to the hedgehog family | 0.903 |
| DHH | SCUBE2 | ENSP00000266991 | ENSP00000429969 | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family | Signal peptide, CUB domain and EGF like domain containing 2 | 0.919 |
| DHH | SHH | ENSP00000266991 | ENSP00000297261 | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family | Sonic hedgehog protein; Sonic hedgehog protein- The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity); Hedgehog signaling molecule family | 0.903 |
| DHH | STK36 | ENSP00000266991 | ENSP00000295709 | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | 0.626 |
| DISP2 | DHH | ENSP00000267889 | ENSP00000266991 | Dispatched RND transporter family member 2 | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family | 0.957 |
| DISP2 | FICD | ENSP00000267889 | ENSP00000446479 | Dispatched RND transporter family member 2 | Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified | 0.544 |
| DISP2 | HEATR5A | ENSP00000267889 | ENSP00000437968 | Dispatched RND transporter family member 2 | HEAT repeat-containing protein 5A; Armadillo-like helical domain containing | 0.520 |
| DISP2 | IHH | ENSP00000267889 | ENSP00000295731 | Dispatched RND transporter family member 2 | Indian hedgehog protein; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity); Belongs to the hedgehog family | 0.957 |
| DISP2 | KIAA2013 | ENSP00000267889 | ENSP00000365756 | Dispatched RND transporter family member 2 | Uncharacterized protein KIAA2013; KIAA2013 | 0.757 |
| DISP2 | MANEAL | ENSP00000267889 | ENSP00000362136 | Dispatched RND transporter family member 2 | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family | 0.669 |
| DISP2 | NAA15 | ENSP00000267889 | ENSP00000296543 | Dispatched RND transporter family member 2 | N-alpha-acetyltransferase 15, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter; Armadillo-like helical domain containing | 0.697 |
| DISP2 | SCUBE2 | ENSP00000267889 | ENSP00000429969 | Dispatched RND transporter family member 2 | Signal peptide, CUB domain and EGF like domain containing 2 | 0.904 |
| DISP2 | SHH | ENSP00000267889 | ENSP00000297261 | Dispatched RND transporter family member 2 | Sonic hedgehog protein; Sonic hedgehog protein- The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity); Hedgehog signaling molecule family | 0.964 |
| DISP2 | STK36 | ENSP00000267889 | ENSP00000295709 | Dispatched RND transporter family member 2 | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | 0.551 |
| FICD | DISP2 | ENSP00000446479 | ENSP00000267889 | Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified | Dispatched RND transporter family member 2 | 0.544 |
| FICD | KIAA2013 | ENSP00000446479 | ENSP00000365756 | Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified | Uncharacterized protein KIAA2013; KIAA2013 | 0.792 |
| HEATR5A | DISP2 | ENSP00000437968 | ENSP00000267889 | HEAT repeat-containing protein 5A; Armadillo-like helical domain containing | Dispatched RND transporter family member 2 | 0.520 |
| IHH | DHH | ENSP00000295731 | ENSP00000266991 | Indian hedgehog protein; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity); Belongs to the hedgehog family | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family | 0.903 |
| IHH | DISP2 | ENSP00000295731 | ENSP00000267889 | Indian hedgehog protein; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity); Belongs to the hedgehog family | Dispatched RND transporter family member 2 | 0.957 |
