SRP14 protein (human) - STRING database

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SRP14

Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (136 aa)

Predicted Functional Partners:

SRP9

0.999

SRP68

0.999

SRP54

0.999

SRP19

0.999

SRP72

0.999

RPS17

0.998

RPL30

0.998

RPL27

0.998

RPS25

0.998

RPS27

0.998

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RPL27	RPL30	ENSP00000464813	ENSP00000428085	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	0.999
RPL27	RPS17	ENSP00000464813	ENSP00000346046	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Ribosomal protein S17	0.999
RPL27	RPS25	ENSP00000464813	ENSP00000435096	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Ribosomal protein S25	0.999
RPL27	RPS27	ENSP00000464813	ENSP00000357555	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family	0.999
RPL27	SRP14	ENSP00000464813	ENSP00000267884	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding	0.998
RPL27	SRP19	ENSP00000464813	ENSP00000424870	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	0.996
RPL27	SRP54	ENSP00000464813	ENSP00000451818	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)	0.996
RPL27	SRP68	ENSP00000464813	ENSP00000312066	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function	0.981
RPL27	SRP72	ENSP00000464813	ENSP00000342181	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function; Belongs to the SRP72 family	0.972
RPL27	SRP9	ENSP00000464813	ENSP00000305230	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding	0.996
RPL30	RPL27	ENSP00000428085	ENSP00000464813	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs	0.999
RPL30	RPS17	ENSP00000428085	ENSP00000346046	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Ribosomal protein S17	0.999
RPL30	RPS25	ENSP00000428085	ENSP00000435096	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Ribosomal protein S25	0.999
RPL30	RPS27	ENSP00000428085	ENSP00000357555	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family	0.999
RPL30	SRP14	ENSP00000428085	ENSP00000267884	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding	0.998
RPL30	SRP19	ENSP00000428085	ENSP00000424870	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	0.996
RPL30	SRP54	ENSP00000428085	ENSP00000451818	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)	0.996
RPL30	SRP68	ENSP00000428085	ENSP00000312066	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function	0.980
RPL30	SRP72	ENSP00000428085	ENSP00000342181	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function; Belongs to the SRP72 family	0.904
RPL30	SRP9	ENSP00000428085	ENSP00000305230	Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding	0.997

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