| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP4E1 | FAM214A | ENSP00000261842 | ENSP00000443598 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | 0.437 |
| AP4E1 | LYSMD2 | ENSP00000261842 | ENSP00000267838 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | 0.510 |
| AP4E1 | TNFAIP8L3 | ENSP00000261842 | ENSP00000328016 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.441 |
| ARPP19 | FAM214A | ENSP00000455625 | ENSP00000443598 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression; Belongs to the endosulfine family | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | 0.773 |
| ARPP19 | LYSMD2 | ENSP00000455625 | ENSP00000267838 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression; Belongs to the endosulfine family | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | 0.479 |
| CMPK2 | LYSMD2 | ENSP00000256722 | ENSP00000267838 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | 0.454 |
| DMXL2 | FAM214A | ENSP00000441858 | ENSP00000443598 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | 0.472 |
| DMXL2 | LYSMD2 | ENSP00000441858 | ENSP00000267838 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | 0.668 |
| DMXL2 | TNFAIP8L3 | ENSP00000441858 | ENSP00000328016 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.517 |
| FAM214A | AP4E1 | ENSP00000443598 | ENSP00000261842 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | 0.437 |
| FAM214A | ARPP19 | ENSP00000443598 | ENSP00000455625 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression; Belongs to the endosulfine family | 0.773 |
| FAM214A | DMXL2 | ENSP00000443598 | ENSP00000441858 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | 0.472 |
| FAM214A | LYSMD2 | ENSP00000443598 | ENSP00000267838 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | 0.684 |
| FAM214A | MYO5C | ENSP00000443598 | ENSP00000261839 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | Unconventional myosin-Vc; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues; Myosins, class V | 0.418 |
| LCN9 | LYSMD2 | ENSP00000277526 | ENSP00000267838 | Epididymal-specific lipocalin-9; Lipocalin 9; Lipocalins | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | 0.533 |
| LYSMD2 | AP4E1 | ENSP00000267838 | ENSP00000261842 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | 0.510 |
| LYSMD2 | ARPP19 | ENSP00000267838 | ENSP00000455625 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression; Belongs to the endosulfine family | 0.479 |
| LYSMD2 | CMPK2 | ENSP00000267838 | ENSP00000256722 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity | 0.454 |
| LYSMD2 | DMXL2 | ENSP00000267838 | ENSP00000441858 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | 0.668 |
| LYSMD2 | FAM214A | ENSP00000267838 | ENSP00000443598 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family | 0.684 |
