node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MFAP1 | MFAP2 | ENSP00000267812 | ENSP00000364685 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family | 0.979 |
MFAP1 | PRPF3 | ENSP00000267812 | ENSP00000315379 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.987 |
MFAP1 | PRPF31 | ENSP00000267812 | ENSP00000324122 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.976 |
MFAP1 | PRPF38A | ENSP00000267812 | ENSP00000257181 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | 0.998 |
MFAP1 | SART1 | ENSP00000267812 | ENSP00000310448 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to the SNU66/SART1 family | 0.992 |
MFAP1 | SF3B1 | ENSP00000267812 | ENSP00000335321 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.985 |
MFAP1 | SMU1 | ENSP00000267812 | ENSP00000380336 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | WD40 repeat-containing protein SMU1; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis. Required for normal accumulation of IK; Belongs to the WD repeat SMU1 family | 0.994 |
MFAP1 | SNRNP200 | ENSP00000267812 | ENSP00000317123 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome | 0.980 |
MFAP1 | SNRPD2 | ENSP00000267812 | ENSP00000342374 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Small nuclear ribonucleoprotein Sm D2; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP | 0.979 |
MFAP1 | ZMAT2 | ENSP00000267812 | ENSP00000274712 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Zinc finger matrin-type 2; Spliceosomal B complex | 0.989 |
MFAP2 | MFAP1 | ENSP00000364685 | ENSP00000267812 | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | 0.979 |
PRPF3 | MFAP1 | ENSP00000315379 | ENSP00000267812 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | 0.987 |
PRPF3 | PRPF31 | ENSP00000315379 | ENSP00000324122 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.999 |
PRPF3 | PRPF38A | ENSP00000315379 | ENSP00000257181 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | 0.997 |
PRPF3 | SART1 | ENSP00000315379 | ENSP00000310448 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to the SNU66/SART1 family | 0.999 |
PRPF3 | SF3B1 | ENSP00000315379 | ENSP00000335321 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.999 |
PRPF3 | SMU1 | ENSP00000315379 | ENSP00000380336 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | WD40 repeat-containing protein SMU1; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis. Required for normal accumulation of IK; Belongs to the WD repeat SMU1 family | 0.996 |
PRPF3 | SNRNP200 | ENSP00000315379 | ENSP00000317123 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome | 0.999 |
PRPF3 | SNRPD2 | ENSP00000315379 | ENSP00000342374 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Small nuclear ribonucleoprotein Sm D2; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP | 0.999 |
PRPF3 | ZMAT2 | ENSP00000315379 | ENSP00000274712 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Zinc finger matrin-type 2; Spliceosomal B complex | 0.994 |