| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO | CSAD | ENSP00000362888 | ENSP00000267085 | 2-aminoethanethiol dioxygenase | Cysteine sulfinic acid decarboxylase | 0.951 |
| ADO | GAD2 | ENSP00000362888 | ENSP00000365437 | 2-aminoethanethiol dioxygenase | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.900 |
| BAAT | CSAD | ENSP00000259407 | ENSP00000267085 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Cysteine sulfinic acid decarboxylase | 0.916 |
| BAAT | GAD2 | ENSP00000259407 | ENSP00000365437 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.901 |
| BAAT | GGT1 | ENSP00000259407 | ENSP00000383232 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Glutathione hydrolase 1 proenzyme; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione ( [...] | 0.906 |
| BAAT | GGT5 | ENSP00000259407 | ENSP00000381340 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.900 |
| BAAT | GGT6 | ENSP00000259407 | ENSP00000370962 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.900 |
| BAAT | GGT7 | ENSP00000259407 | ENSP00000338964 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.900 |
| CDO1 | CSAD | ENSP00000250535 | ENSP00000267085 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | Cysteine sulfinic acid decarboxylase | 0.960 |
| CDO1 | GAD2 | ENSP00000250535 | ENSP00000365437 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.918 |
| CDO1 | GOT1 | ENSP00000250535 | ENSP00000359539 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- [...] | 0.922 |
| CSAD | ADO | ENSP00000267085 | ENSP00000362888 | Cysteine sulfinic acid decarboxylase | 2-aminoethanethiol dioxygenase | 0.951 |
| CSAD | BAAT | ENSP00000267085 | ENSP00000259407 | Cysteine sulfinic acid decarboxylase | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | 0.916 |
| CSAD | CDO1 | ENSP00000267085 | ENSP00000250535 | Cysteine sulfinic acid decarboxylase | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | 0.960 |
| CSAD | GAD2 | ENSP00000267085 | ENSP00000365437 | Cysteine sulfinic acid decarboxylase | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.837 |
| CSAD | GGT1 | ENSP00000267085 | ENSP00000383232 | Cysteine sulfinic acid decarboxylase | Glutathione hydrolase 1 proenzyme; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione ( [...] | 0.906 |
| CSAD | GGT5 | ENSP00000267085 | ENSP00000381340 | Cysteine sulfinic acid decarboxylase | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.910 |
| CSAD | GGT6 | ENSP00000267085 | ENSP00000370962 | Cysteine sulfinic acid decarboxylase | Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.911 |
| CSAD | GGT7 | ENSP00000267085 | ENSP00000338964 | Cysteine sulfinic acid decarboxylase | Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.904 |
| CSAD | GOT1 | ENSP00000267085 | ENSP00000359539 | Cysteine sulfinic acid decarboxylase | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- [...] | 0.865 |
