| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADSS | ADSSL1 | ENSP00000355493 | ENSP00000333019 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.940 |
| ADSS | AMDHD1 | ENSP00000355493 | ENSP00000266736 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | 0.559 |
| ADSS | APRT | ENSP00000355493 | ENSP00000367615 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.846 |
| ADSS | FTCD | ENSP00000355493 | ENSP00000291670 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | 0.800 |
| ADSSL1 | ADSS | ENSP00000333019 | ENSP00000355493 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.940 |
| ADSSL1 | AMDHD1 | ENSP00000333019 | ENSP00000266736 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | 0.594 |
| ADSSL1 | APRT | ENSP00000333019 | ENSP00000367615 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.786 |
| ADSSL1 | FTCD | ENSP00000333019 | ENSP00000291670 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | 0.800 |
| AMDHD1 | ADSS | ENSP00000266736 | ENSP00000355493 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.559 |
| AMDHD1 | ADSSL1 | ENSP00000266736 | ENSP00000333019 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.594 |
| AMDHD1 | APRT | ENSP00000266736 | ENSP00000367615 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.558 |
| AMDHD1 | FTCD | ENSP00000266736 | ENSP00000291670 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | 0.971 |
| AMDHD1 | HAL | ENSP00000266736 | ENSP00000261208 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Histidine ammonia-lyase | 0.911 |
| AMDHD1 | HMGCL | ENSP00000266736 | ENSP00000363614 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism | 0.559 |
| AMDHD1 | MAGEF1 | ENSP00000266736 | ENSP00000315064 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Melanoma-associated antigen F1; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex; MAGE family | 0.589 |
| AMDHD1 | MEAF6 | ENSP00000266736 | ENSP00000362166 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | 0.508 |
| AMDHD1 | PPP1R14C | ENSP00000266736 | ENSP00000355260 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | 0.530 |
| AMDHD1 | UROC1 | ENSP00000266736 | ENSP00000373073 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Urocanate hydratase 1 | 0.987 |
| APRT | ADSS | ENSP00000367615 | ENSP00000355493 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.846 |
| APRT | ADSSL1 | ENSP00000367615 | ENSP00000333019 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.786 |
