| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BIVM | TMTC3 | ENSP00000257336 | ENSP00000266712 | Basic, immunoglobulin-like variable motif containing | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.607 |
| C17orf62 | DHRS7 | ENSP00000388909 | ENSP00000216500 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | 0.716 |
| C17orf62 | POPDC2 | ENSP00000388909 | ENSP00000264231 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | 0.536 |
| C17orf62 | TMEM199 | ENSP00000388909 | ENSP00000292114 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.730 |
| C17orf62 | TMEM201 | ENSP00000388909 | ENSP00000344503 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery | 0.555 |
| C17orf62 | TMTC3 | ENSP00000388909 | ENSP00000266712 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.621 |
| DHRS7 | C17orf62 | ENSP00000216500 | ENSP00000388909 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | 0.716 |
| DHRS7 | POPDC2 | ENSP00000216500 | ENSP00000264231 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | 0.598 |
| DHRS7 | TMEM199 | ENSP00000216500 | ENSP00000292114 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.559 |
| DHRS7 | TMEM201 | ENSP00000216500 | ENSP00000344503 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery | 0.565 |
| DHRS7 | TMTC3 | ENSP00000216500 | ENSP00000266712 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.646 |
| LMBRD2 | TMTC3 | ENSP00000296603 | ENSP00000266712 | LMBR1 domain containing 2 | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.636 |
| NANS | TMTC3 | ENSP00000210444 | ENSP00000266712 | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.708 |
| POPDC2 | C17orf62 | ENSP00000264231 | ENSP00000388909 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | 0.536 |
| POPDC2 | DHRS7 | ENSP00000264231 | ENSP00000216500 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | 0.598 |
| POPDC2 | TMEM199 | ENSP00000264231 | ENSP00000292114 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.577 |
| POPDC2 | TMEM201 | ENSP00000264231 | ENSP00000344503 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery | 0.625 |
| POPDC2 | TMTC3 | ENSP00000264231 | ENSP00000266712 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.640 |
| PRR14L | QSER1 | ENSP00000331845 | ENSP00000382241 | Protein PRR14L; Proline rich 14 like | Glutamine and serine rich 1 | 0.738 |
| PRR14L | TMTC3 | ENSP00000331845 | ENSP00000266712 | Protein PRR14L; Proline rich 14 like | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.729 |
