node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC59 | LLPH | ENSP00000256151 | ENSP00000266604 | Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | 0.752 |
DDX31 | HELB | ENSP00000361232 | ENSP00000247815 | Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily | DNA helicase B; 5’-3’ DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5’-3’ ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5’-3’ polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP [...] | 0.417 |
DDX31 | LLPH | ENSP00000361232 | ENSP00000266604 | Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | 0.675 |
DDX31 | NHP2 | ENSP00000361232 | ENSP00000274606 | Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.595 |
HELB | DDX31 | ENSP00000247815 | ENSP00000361232 | DNA helicase B; 5’-3’ DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5’-3’ ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5’-3’ polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP [...] | Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily | 0.417 |
HELB | LLPH | ENSP00000247815 | ENSP00000266604 | DNA helicase B; 5’-3’ DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5’-3’ ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5’-3’ polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP [...] | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | 0.724 |
LLPH | CCDC59 | ENSP00000266604 | ENSP00000256151 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | 0.752 |
LLPH | DDX31 | ENSP00000266604 | ENSP00000361232 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily | 0.675 |
LLPH | HELB | ENSP00000266604 | ENSP00000247815 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | DNA helicase B; 5’-3’ DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5’-3’ ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5’-3’ polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP [...] | 0.724 |
LLPH | NHP2 | ENSP00000266604 | ENSP00000274606 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.826 |
LLPH | NOP16 | ENSP00000266604 | ENSP00000480832 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | NOP16 nucleolar protein; Belongs to the NOP16 family | 0.833 |
LLPH | NPM2 | ENSP00000266604 | ENSP00000381032 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization; Belongs to the nucleoplasmin family | 0.652 |
LLPH | PATE2 | ENSP00000266604 | ENSP00000351325 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | Prostate and testis expressed 2; LY6/PLAUR domain containing | 0.598 |
LLPH | POLR1D | ENSP00000266604 | ENSP00000302478 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | DNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively; Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family | 0.832 |
LLPH | SNRPB2 | ENSP00000266604 | ENSP00000246071 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | U2 small nuclear ribonucleoprotein B’; Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A’ protein; RNA binding motif containing | 0.617 |
LLPH | SSBP1 | ENSP00000266604 | ENSP00000419665 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | Single-stranded DNA-binding protein, mitochondrial; This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA | 0.660 |
NHP2 | DDX31 | ENSP00000274606 | ENSP00000361232 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily | 0.595 |
NHP2 | LLPH | ENSP00000274606 | ENSP00000266604 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission | 0.826 |
NHP2 | NOP16 | ENSP00000274606 | ENSP00000480832 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | NOP16 nucleolar protein; Belongs to the NOP16 family | 0.930 |
NHP2 | NPM2 | ENSP00000274606 | ENSP00000381032 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization; Belongs to the nucleoplasmin family | 0.750 |