| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PDCD7 | RNPC3 | ENSP00000204549 | ENSP00000432886 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | 0.935 |
| PDCD7 | SF3B1 | ENSP00000204549 | ENSP00000335321 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.900 |
| PDCD7 | SF3B2 | ENSP00000204549 | ENSP00000318861 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.900 |
| PDCD7 | SNRNP35 | ENSP00000204549 | ENSP00000403310 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Small nuclear ribonucleoprotein U11/U12 subunit 35; RNA binding motif containing | 0.993 |
| PDCD7 | SNRNP48 | ENSP00000204549 | ENSP00000339834 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5’ splice site recognition; U11/U12 di-snRNP | 0.900 |
| PDCD7 | SRSF1 | ENSP00000204549 | ENSP00000258962 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.914 |
| PDCD7 | YBX1 | ENSP00000204549 | ENSP00000361626 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Nuclease-sensitive element-binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTG [...] | 0.900 |
| PDCD7 | ZCRB1 | ENSP00000204549 | ENSP00000266529 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Zinc finger CCHC-type and RNA binding motif containing 1 | 0.957 |
| PDCD7 | ZMAT5 | ENSP00000204549 | ENSP00000344241 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Zinc finger matrin-type 5; U11/U12 di-snRNP | 0.985 |
| PDCD7 | ZRSR2 | ENSP00000204549 | ENSP00000303015 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3’-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing | 0.979 |
| RNPC3 | PDCD7 | ENSP00000432886 | ENSP00000204549 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | 0.935 |
| RNPC3 | SF3B1 | ENSP00000432886 | ENSP00000335321 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.978 |
| RNPC3 | SF3B2 | ENSP00000432886 | ENSP00000318861 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.970 |
| RNPC3 | SNRNP35 | ENSP00000432886 | ENSP00000403310 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Small nuclear ribonucleoprotein U11/U12 subunit 35; RNA binding motif containing | 0.988 |
| RNPC3 | SNRNP48 | ENSP00000432886 | ENSP00000339834 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5’ splice site recognition; U11/U12 di-snRNP | 0.942 |
| RNPC3 | SRSF1 | ENSP00000432886 | ENSP00000258962 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.929 |
| RNPC3 | YBX1 | ENSP00000432886 | ENSP00000361626 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Nuclease-sensitive element-binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTG [...] | 0.904 |
| RNPC3 | ZCRB1 | ENSP00000432886 | ENSP00000266529 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Zinc finger CCHC-type and RNA binding motif containing 1 | 0.975 |
| RNPC3 | ZMAT5 | ENSP00000432886 | ENSP00000344241 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Zinc finger matrin-type 5; U11/U12 di-snRNP | 0.992 |
| RNPC3 | ZRSR2 | ENSP00000432886 | ENSP00000303015 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3’-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing | 0.993 |
