ETNK1 protein (human) - STRING database

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ETNK1

Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis (452 aa)

Predicted Functional Partners:

PCYT2

0.967

ETNPPL

0.925

GPCPD1

0.914

SOX5

0.800

ORC4

0.717

GOLT1A

0.707

ALDH16A1

0.702

PIK3C2B

0.694

PISD

0.691

EPT1

0.680

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH16A1	ETNK1	ENSP00000293350	ENSP00000266517	Aldehyde dehydrogenase 16 family member A1	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	0.702
ALDH16A1	GOLT1A	ENSP00000293350	ENSP00000308535	Aldehyde dehydrogenase 16 family member A1	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	0.678
ALDH16A1	PIK3C2B	ENSP00000293350	ENSP00000356155	Aldehyde dehydrogenase 16 family member A1	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades; Belongs to the PI3/PI4-kinase family	0.629
EPT1	ETNK1	ENSP00000260585	ENSP00000266517	Ethanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	0.680
EPT1	PCYT2	ENSP00000260585	ENSP00000442050	Ethanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine	0.971
EPT1	PISD	ENSP00000260585	ENSP00000371586	Ethanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine; Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily	0.960
ETNK1	ALDH16A1	ENSP00000266517	ENSP00000293350	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Aldehyde dehydrogenase 16 family member A1	0.702
ETNK1	EPT1	ENSP00000266517	ENSP00000260585	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Ethanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	0.680
ETNK1	ETNPPL	ENSP00000266517	ENSP00000296486	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde	0.925
ETNK1	GOLT1A	ENSP00000266517	ENSP00000308535	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	0.707
ETNK1	GPCPD1	ENSP00000266517	ENSP00000368305	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity; Belongs to the glycerophosphoryl diester phosphodiesterase family	0.914
ETNK1	ORC4	ENSP00000266517	ENSP00000441953	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3; Belongs to the ORC4 family	0.717
ETNK1	PCYT2	ENSP00000266517	ENSP00000442050	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine	0.967
ETNK1	PIK3C2B	ENSP00000266517	ENSP00000356155	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades; Belongs to the PI3/PI4-kinase family	0.694
ETNK1	PISD	ENSP00000266517	ENSP00000371586	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine; Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily	0.691
ETNK1	SOX5	ENSP00000266517	ENSP00000398273	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes	0.800
ETNPPL	ETNK1	ENSP00000296486	ENSP00000266517	Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	0.925
ETNPPL	PCYT2	ENSP00000296486	ENSP00000442050	Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde	Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine	0.900
GOLT1A	ALDH16A1	ENSP00000308535	ENSP00000293350	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	Aldehyde dehydrogenase 16 family member A1	0.678
GOLT1A	ETNK1	ENSP00000308535	ENSP00000266517	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis	0.707

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