| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD8A | CD8B | ENSP00000386559 | ENSP00000331172 | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] | 0.996 |
| CD8A | PATZ1 | ENSP00000386559 | ENSP00000266269 | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.649 |
| CD8B | CD8A | ENSP00000331172 | ENSP00000386559 | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] | 0.996 |
| CD8B | NCOR1 | ENSP00000331172 | ENSP00000268712 | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6 | 0.501 |
| CD8B | PATZ1 | ENSP00000331172 | ENSP00000266269 | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.756 |
| CD8B | RNF4 | ENSP00000331172 | ENSP00000426503 | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] | E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates ’Lys-6’-, ’Lys-11’-, ’Lys-48’- and ’Lys-63’-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular [...] | 0.627 |
| FADS1 | PATZ1 | ENSP00000322229 | ENSP00000266269 | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20-3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20-3n-6) and eicosatetraenoic acid (20-4n-3) to generate arachidonic acid (AA) (20-4n-6) and eicosapentaenoic acid (EPA)(20-5n-3), [...] | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.636 |
| HDHD3 | PATZ1 | ENSP00000238379 | ENSP00000266269 | Haloacid dehalogenase like hydrolase domain containing 3 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.646 |
| HDHD3 | TLDC1 | ENSP00000238379 | ENSP00000343635 | Haloacid dehalogenase like hydrolase domain containing 3 | TLD domain-containing protein 1; TBC/LysM-associated domain containing 1 | 0.760 |
| NCOR1 | CD8B | ENSP00000268712 | ENSP00000331172 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6 | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] | 0.501 |
| NCOR1 | PATZ1 | ENSP00000268712 | ENSP00000266269 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.634 |
| NCOR1 | TP53 | ENSP00000268712 | ENSP00000269305 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.721 |
| PATZ1 | CD8A | ENSP00000266269 | ENSP00000386559 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] | 0.649 |
| PATZ1 | CD8B | ENSP00000266269 | ENSP00000331172 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule-peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] | 0.756 |
| PATZ1 | FADS1 | ENSP00000266269 | ENSP00000322229 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20-3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20-3n-6) and eicosatetraenoic acid (20-4n-3) to generate arachidonic acid (AA) (20-4n-6) and eicosapentaenoic acid (EPA)(20-5n-3), [...] | 0.636 |
| PATZ1 | HDHD3 | ENSP00000266269 | ENSP00000238379 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | Haloacid dehalogenase like hydrolase domain containing 3 | 0.646 |
| PATZ1 | NCOR1 | ENSP00000266269 | ENSP00000268712 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6 | 0.634 |
| PATZ1 | RNF4 | ENSP00000266269 | ENSP00000426503 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates ’Lys-6’-, ’Lys-11’-, ’Lys-48’- and ’Lys-63’-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular [...] | 0.776 |
| PATZ1 | TLDC1 | ENSP00000266269 | ENSP00000343635 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | TLD domain-containing protein 1; TBC/LysM-associated domain containing 1 | 0.726 |
| PATZ1 | TOPORS | ENSP00000266269 | ENSP00000353735 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | E3 ubiquitin-protein ligase Topors; Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation; Ring finger proteins | 0.597 |
