node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGBL4 | TTLL1 | ENSP00000360905 | ENSP00000266254 | Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS/MB21D1, regulating the antiviral activity of CGAS/MB21D1. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed b [...] | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.754 |
AGBL4 | TTLL12 | ENSP00000360905 | ENSP00000216129 | Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS/MB21D1, regulating the antiviral activity of CGAS/MB21D1. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed b [...] | Tubulin--tyrosine ligase-like protein 12; Tubulin tyrosine ligase like 12 | 0.493 |
AGTPBP1 | TTLL1 | ENSP00000338512 | ENSP00000266254 | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5; Armadillo-like helical domain containing | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.722 |
C11orf49 | LRRC49 | ENSP00000367878 | ENSP00000453273 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.914 |
C11orf49 | NICN1 | ENSP00000367878 | ENSP00000273598 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Nicolin-1; Nicolin 1 | 0.835 |
C11orf49 | TPGS2 | ENSP00000367878 | ENSP00000464780 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Tubulin polyglutamylase complex subunit 2 | 0.857 |
C11orf49 | TTLL1 | ENSP00000367878 | ENSP00000266254 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.822 |
KIAA1841 | LRRC49 | ENSP00000385579 | ENSP00000453273 | Uncharacterized protein KIAA1841; KIAA1841 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.851 |
KIAA1841 | NICN1 | ENSP00000385579 | ENSP00000273598 | Uncharacterized protein KIAA1841; KIAA1841 | Nicolin-1; Nicolin 1 | 0.829 |
KIAA1841 | TTLL1 | ENSP00000385579 | ENSP00000266254 | Uncharacterized protein KIAA1841; KIAA1841 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.874 |
LRRC49 | C11orf49 | ENSP00000453273 | ENSP00000367878 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.914 |
LRRC49 | KIAA1841 | ENSP00000453273 | ENSP00000385579 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Uncharacterized protein KIAA1841; KIAA1841 | 0.851 |
LRRC49 | NICN1 | ENSP00000453273 | ENSP00000273598 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Nicolin-1; Nicolin 1 | 0.982 |
LRRC49 | TBC1D19 | ENSP00000453273 | ENSP00000264866 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.843 |
LRRC49 | TPGS1 | ENSP00000453273 | ENSP00000352265 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Tubulin polyglutamylase complex subunit 1; May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity) | 0.991 |
LRRC49 | TPGS2 | ENSP00000453273 | ENSP00000464780 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Tubulin polyglutamylase complex subunit 2 | 0.981 |
LRRC49 | TTLL1 | ENSP00000453273 | ENSP00000266254 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.983 |
NICN1 | C11orf49 | ENSP00000273598 | ENSP00000367878 | Nicolin-1; Nicolin 1 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.835 |
NICN1 | KIAA1841 | ENSP00000273598 | ENSP00000385579 | Nicolin-1; Nicolin 1 | Uncharacterized protein KIAA1841; KIAA1841 | 0.829 |
NICN1 | LRRC49 | ENSP00000273598 | ENSP00000453273 | Nicolin-1; Nicolin 1 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.982 |