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  • 11.0 [archived version]
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REG1A REG1A GCG GCG DPP4 DPP4 ADCY7 ADCY7 SLC2A2 SLC2A2 INS INS ILVBL ILVBL SLC5A4 SLC5A4 SLC6A2 SLC6A2 RSC1A1 RSC1A1 RPS13 RPS13
"SLC5A4" - Solute carrier family 5 member 4 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SLC5A4Solute carrier family 5 member 4; Has electrogenic activity in response to glucose, and may function as a glucose sensor. Mediates influx of sodium ions into the cell but does not transport sugars. Also potently activated by imino sugars such as deoxynojirimycin (DNJ); Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family (659 aa)    
Predicted Functional Partners:
DPP4
Dipeptidyl peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] (766 aa)
           
  0.891
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (110 aa)
           
  0.872
REG1A
Lithostathine-1-alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration; C-type lectin domain containing (166 aa)
           
  0.864
ADCY7
Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases (1080 aa)
           
  0.808
SLC6A2
Sodium-dependent noradrenaline transporter; Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily (628 aa)
           
  0.804
RPS13
Ribosomal protein S13 (151 aa)
         
  0.801
RSC1A1
Regulatory solute carrier protein family 1 member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (617 aa)
           
  0.801
GCG
Glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life; Belongs to the glucagon family (180 aa)
           
  0.795
ILVBL
Acetolactate synthase-like protein; ilvB acetolactate synthase like (632 aa)
         
  0.731
SLC2A2
Solute carrier family 2, facilitated glucose transporter member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily (524 aa)
     
   
  0.725
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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