node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000253117 | LY75-CD302 | ENSP00000262283 | ENSP00000423463 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | LY75-CD302 readthrough | 0.620 |
ENSG00000253117 | RBM6 | ENSP00000262283 | ENSP00000266022 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.622 |
ESYT1 | FPGT | ENSP00000267113 | ENSP00000359935 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | 0.633 |
ESYT1 | RBM6 | ENSP00000267113 | ENSP00000266022 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.629 |
ESYT1 | ZC3H10 | ENSP00000267113 | ENSP00000257940 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.851 |
ESYT1 | ZFP91 | ENSP00000267113 | ENSP00000339030 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates ’Lys- 63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.449 |
FPGT | ESYT1 | ENSP00000359935 | ENSP00000267113 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | 0.633 |
FPGT | HHLA1 | ENSP00000359935 | ENSP00000407107 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | HERV-H LTR-associating 1 | 0.593 |
FPGT | RBM6 | ENSP00000359935 | ENSP00000266022 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.632 |
FPGT | ZC3H10 | ENSP00000359935 | ENSP00000257940 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.670 |
FPGT | ZFP91 | ENSP00000359935 | ENSP00000339030 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates ’Lys- 63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.636 |
HHLA1 | FPGT | ENSP00000407107 | ENSP00000359935 | HERV-H LTR-associating 1 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | 0.593 |
HHLA1 | RBM6 | ENSP00000407107 | ENSP00000266022 | HERV-H LTR-associating 1 | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.784 |
HHLA1 | ZC3H10 | ENSP00000407107 | ENSP00000257940 | HERV-H LTR-associating 1 | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.665 |
HHLA1 | ZFP91 | ENSP00000407107 | ENSP00000339030 | HERV-H LTR-associating 1 | E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates ’Lys- 63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.665 |
LY75-CD302 | ENSG00000253117 | ENSP00000423463 | ENSP00000262283 | LY75-CD302 readthrough | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | 0.620 |
LY75-CD302 | RBM6 | ENSP00000423463 | ENSP00000266022 | LY75-CD302 readthrough | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.607 |
QKI | RBM6 | ENSP00000355094 | ENSP00000266022 | Protein quaking; RNA-binding protein that plays a central role in myelinization. Binds to the 5’-NACUAAY-N(1,20)- UAAY-3’ RNA core sequence. Regulates target mRNA stability. In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulat [...] | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.664 |
RBM39 | RBM6 | ENSP00000253363 | ENSP00000266022 | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process; RNA binding motif containing | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.586 |
RBM6 | ENSG00000253117 | ENSP00000266022 | ENSP00000262283 | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | 0.622 |