node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASTN2 | GLT8D1 | ENSP00000354504 | ENSP00000266014 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5- trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6); Fibronectin type III domain containing | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | 0.548 |
ASTN2 | GNL3 | ENSP00000354504 | ENSP00000395772 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5- trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6); Fibronectin type III domain containing | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family | 0.429 |
C6orf136 | GLT8D1 | ENSP00000293604 | ENSP00000266014 | Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | 0.630 |
C6orf136 | SPCS1 | ENSP00000293604 | ENSP00000478310 | Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136 | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum; Belongs to the SPCS1 family | 0.578 |
GLT8D1 | ASTN2 | ENSP00000266014 | ENSP00000354504 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5- trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6); Fibronectin type III domain containing | 0.548 |
GLT8D1 | C6orf136 | ENSP00000266014 | ENSP00000293604 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136 | 0.630 |
GLT8D1 | GNL3 | ENSP00000266014 | ENSP00000395772 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family | 0.661 |
GLT8D1 | ITIH1 | ENSP00000266014 | ENSP00000273283 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes | 0.566 |
GLT8D1 | ITIH3 | ENSP00000266014 | ENSP00000415769 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes | 0.552 |
GLT8D1 | NEK4 | ENSP00000266014 | ENSP00000233027 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage | 0.586 |
GLT8D1 | OR6C65 | ENSP00000266014 | ENSP00000368986 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Olfactory receptor 6C65; Odorant receptor; Olfactory receptors, family 6 | 0.555 |
GLT8D1 | SPCS1 | ENSP00000266014 | ENSP00000478310 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum; Belongs to the SPCS1 family | 0.683 |
GLT8D1 | SUCLG2 | ENSP00000266014 | ENSP00000419325 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit | 0.577 |
GLT8D1 | ZSCAN31 | ENSP00000266014 | ENSP00000390076 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | Zinc finger and SCAN domain-containing protein 31; May function as a transcription factor. May be involved in the development of multiple embryonic organs; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.711 |
GNL3 | ASTN2 | ENSP00000395772 | ENSP00000354504 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5- trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6); Fibronectin type III domain containing | 0.429 |
GNL3 | GLT8D1 | ENSP00000395772 | ENSP00000266014 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | 0.661 |
GNL3 | ITIH1 | ENSP00000395772 | ENSP00000273283 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family | Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes | 0.420 |
GNL3 | NEK4 | ENSP00000395772 | ENSP00000233027 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage | 0.517 |
GNL3 | SPCS1 | ENSP00000395772 | ENSP00000478310 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum; Belongs to the SPCS1 family | 0.414 |
ITIH1 | GLT8D1 | ENSP00000273283 | ENSP00000266014 | Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family | 0.566 |