ADAM18 protein (human) - STRING database

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ADAM18

Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing (739 aa)

Predicted Functional Partners:

TMEM121

0.565

ATAD3C

0.530

SPACA1

0.527

TGFA

0.515

PLEKHA2

0.499

SPACA4

0.478

TSSK2

0.454

IZUMO2

0.452

IZUMO4

0.446

IZUMO3

0.443

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM18	ATAD3C	ENSP00000265707	ENSP00000368062	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	0.530
ADAM18	IZUMO2	ENSP00000265707	ENSP00000293405	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.452
ADAM18	IZUMO3	ENSP00000265707	ENSP00000474246	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.443
ADAM18	IZUMO4	ENSP00000265707	ENSP00000378712	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.446
ADAM18	PLEKHA2	ENSP00000265707	ENSP00000482228	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.499
ADAM18	SPACA1	ENSP00000265707	ENSP00000237201	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion	0.527
ADAM18	SPACA4	ENSP00000265707	ENSP00000312774	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing	0.478
ADAM18	TGFA	ENSP00000265707	ENSP00000295400	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar	0.515
ADAM18	TMEM121	ENSP00000265707	ENSP00000376304	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family	0.565
ADAM18	TSSK2	ENSP00000265707	ENSP00000382544	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body	0.454
ATAD3C	ADAM18	ENSP00000368062	ENSP00000265707	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	0.530
ATAD3C	TMEM121	ENSP00000368062	ENSP00000376304	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family	0.475
IZUMO2	ADAM18	ENSP00000293405	ENSP00000265707	Izumo sperm-egg fusion protein 2; IZUMO family member 2	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	0.452
IZUMO2	IZUMO3	ENSP00000293405	ENSP00000474246	Izumo sperm-egg fusion protein 2; IZUMO family member 2	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.857
IZUMO2	IZUMO4	ENSP00000293405	ENSP00000378712	Izumo sperm-egg fusion protein 2; IZUMO family member 2	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.895
IZUMO3	ADAM18	ENSP00000474246	ENSP00000265707	Izumo sperm-egg fusion protein 3; IZUMO family member 3	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	0.443
IZUMO3	IZUMO2	ENSP00000474246	ENSP00000293405	Izumo sperm-egg fusion protein 3; IZUMO family member 3	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.857
IZUMO3	IZUMO4	ENSP00000474246	ENSP00000378712	Izumo sperm-egg fusion protein 3; IZUMO family member 3	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.861
IZUMO4	ADAM18	ENSP00000378712	ENSP00000265707	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing	0.446
IZUMO4	IZUMO2	ENSP00000378712	ENSP00000293405	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.895

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