node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEBPE | CSF2RB | ENSP00000206513 | ENSP00000384053 | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | 0.576 |
CEBPE | CSF3R | ENSP00000206513 | ENSP00000362195 | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | 0.668 |
CEBPE | LY86 | ENSP00000206513 | ENSP00000369286 | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity) | 0.556 |
CEBPE | SPI1 | ENSP00000206513 | ENSP00000227163 | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity); Belongs to the ETS family | 0.826 |
CEBPE | STAB1 | ENSP00000206513 | ENSP00000312946 | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | Stabilin-1; Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system | 0.482 |
CEBPE | TFEC | ENSP00000206513 | ENSP00000265440 | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] | 0.621 |
CSF2RB | CEBPE | ENSP00000384053 | ENSP00000206513 | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | 0.576 |
CSF2RB | CSF3R | ENSP00000384053 | ENSP00000362195 | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | 0.697 |
CSF2RB | LY86 | ENSP00000384053 | ENSP00000369286 | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity) | 0.643 |
CSF2RB | SPI1 | ENSP00000384053 | ENSP00000227163 | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity); Belongs to the ETS family | 0.761 |
CSF2RB | STAB1 | ENSP00000384053 | ENSP00000312946 | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | Stabilin-1; Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system | 0.443 |
CSF2RB | TFEC | ENSP00000384053 | ENSP00000265440 | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] | 0.706 |
CSF3R | CEBPE | ENSP00000362195 | ENSP00000206513 | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily | 0.668 |
CSF3R | CSF2RB | ENSP00000362195 | ENSP00000384053 | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules | 0.697 |
CSF3R | LY86 | ENSP00000362195 | ENSP00000369286 | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity) | 0.570 |
CSF3R | SPI1 | ENSP00000362195 | ENSP00000227163 | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity); Belongs to the ETS family | 0.846 |
CSF3R | STAB1 | ENSP00000362195 | ENSP00000312946 | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | Stabilin-1; Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system | 0.458 |
CSF3R | TFEC | ENSP00000362195 | ENSP00000265440 | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface; CD molecules | Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] | 0.651 |
CTSK | SPI1 | ENSP00000271651 | ENSP00000227163 | Cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation; Cathepsins | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity); Belongs to the ETS family | 0.555 |
CTSK | TFEB | ENSP00000271651 | ENSP00000351742 | Cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation; Cathepsins | Transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5’-CANNTG-3’). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5’-GTCACGTGAC-3’) present in the regulatory region of many lysosomal genes, leading to activate the [...] | 0.718 |