node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCK1 | CDKL3 | ENSP00000238561 | ENSP00000265334 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | 0.552 |
ADCK1 | PI4KB | ENSP00000238561 | ENSP00000357869 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | 0.498 |
ALG2 | CDKL3 | ENSP00000417764 | ENSP00000265334 | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | 0.626 |
ALG2 | COX15 | ENSP00000417764 | ENSP00000016171 | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A; Mitochondrial respiratory chain complex assembly factors | 0.558 |
ALG2 | LAMA4 | ENSP00000417764 | ENSP00000230538 | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.634 |
C9orf142 | CDKL3 | ENSP00000360682 | ENSP00000265334 | Protein PAXX; Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | 0.517 |
CDKL3 | ADCK1 | ENSP00000265334 | ENSP00000238561 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.552 |
CDKL3 | ALG2 | ENSP00000265334 | ENSP00000417764 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | 0.626 |
CDKL3 | C9orf142 | ENSP00000265334 | ENSP00000360682 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Protein PAXX; Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery | 0.517 |
CDKL3 | COX15 | ENSP00000265334 | ENSP00000016171 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A; Mitochondrial respiratory chain complex assembly factors | 0.610 |
CDKL3 | LAMA4 | ENSP00000265334 | ENSP00000230538 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.647 |
CDKL3 | PI4KB | ENSP00000265334 | ENSP00000357869 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | 0.466 |
CDKL3 | SLMO1 | ENSP00000265334 | ENSP00000404700 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | PRELI domain containing protein 3A; In vitro, the TRIAP1-PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane; Belongs to the slowmo family | 0.458 |
CDKL3 | STAMBP | ENSP00000265334 | ENSP00000377633 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | STAM-binding protein; Zinc metalloprotease that specifically cleaves ’Lys-63’- linked polyubiquitin chains. Does not cleave ’Lys-48’-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degr [...] | 0.516 |
CDKL3 | TMEM138 | ENSP00000265334 | ENSP00000278826 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Transmembrane protein 138; Required for ciliogenesis | 0.456 |
CDKL3 | ZNF473 | ENSP00000265334 | ENSP00000472808 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | Zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases; Zinc fingers C2H2-type | 0.461 |
COX15 | ALG2 | ENSP00000016171 | ENSP00000417764 | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A; Mitochondrial respiratory chain complex assembly factors | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | 0.558 |
COX15 | CDKL3 | ENSP00000016171 | ENSP00000265334 | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A; Mitochondrial respiratory chain complex assembly factors | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 | 0.610 |
COX15 | LAMA4 | ENSP00000016171 | ENSP00000230538 | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A; Mitochondrial respiratory chain complex assembly factors | Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.574 |
LAMA4 | ALG2 | ENSP00000230538 | ENSP00000417764 | Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | 0.634 |