| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C2orf73 | FAM188B | ENSP00000381631 | ENSP00000265299 | Uncharacterized protein C2orf73; Chromosome 2 open reading frame 73 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | 0.474 |
| C2orf73 | LRRC66 | ENSP00000381631 | ENSP00000341944 | Uncharacterized protein C2orf73; Chromosome 2 open reading frame 73 | Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66 | 0.576 |
| C4orf22 | FAM188B | ENSP00000425786 | ENSP00000265299 | Uncharacterized protein C4orf22; Chromosome 4 open reading frame 22 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | 0.476 |
| DGKH | FAM188B | ENSP00000337572 | ENSP00000265299 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | 0.570 |
| DGKH | INMT | ENSP00000337572 | ENSP00000013222 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | Indolethylamine N-methyltransferase; Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds; Seven-beta-strand methyltransferase motif containing | 0.441 |
| DGKH | PFN3 | ENSP00000337572 | ENSP00000351379 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis; Belongs to the profilin family | 0.511 |
| DGKH | RGS14 | ENSP00000337572 | ENSP00000386229 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | Regulator of G-protein signaling 14; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pat [...] | 0.447 |
| FAM118B | FAM188B | ENSP00000433343 | ENSP00000265299 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | 0.522 |
| FAM188B | C2orf73 | ENSP00000265299 | ENSP00000381631 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Uncharacterized protein C2orf73; Chromosome 2 open reading frame 73 | 0.474 |
| FAM188B | C4orf22 | ENSP00000265299 | ENSP00000425786 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Uncharacterized protein C4orf22; Chromosome 4 open reading frame 22 | 0.476 |
| FAM188B | DGKH | ENSP00000265299 | ENSP00000337572 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | 0.570 |
| FAM188B | FAM118B | ENSP00000265299 | ENSP00000433343 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.522 |
| FAM188B | INMT | ENSP00000265299 | ENSP00000013222 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Indolethylamine N-methyltransferase; Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds; Seven-beta-strand methyltransferase motif containing | 0.630 |
| FAM188B | LRRC66 | ENSP00000265299 | ENSP00000341944 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66 | 0.491 |
| FAM188B | PFN3 | ENSP00000265299 | ENSP00000351379 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis; Belongs to the profilin family | 0.587 |
| FAM188B | PLEKHA5 | ENSP00000265299 | ENSP00000404296 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Pleckstrin homology domain containing A5 | 0.525 |
| FAM188B | RGS14 | ENSP00000265299 | ENSP00000386229 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Regulator of G-protein signaling 14; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pat [...] | 0.531 |
| FAM188B | SIRPD | ENSP00000265299 | ENSP00000371036 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | Signal regulatory protein delta | 0.539 |
| INMT | DGKH | ENSP00000013222 | ENSP00000337572 | Indolethylamine N-methyltransferase; Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds; Seven-beta-strand methyltransferase motif containing | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | 0.441 |
| INMT | FAM188B | ENSP00000013222 | ENSP00000265299 | Indolethylamine N-methyltransferase; Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds; Seven-beta-strand methyltransferase motif containing | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | 0.630 |
