ARSB protein (human) - STRING database

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ARSB

Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family (533 aa)

Predicted Functional Partners:

SUMF1

0.976

IDUA

0.966

GUSB

0.962

SUMF2

0.951

ARSK

0.949

ARSH

0.941

ARSD

0.937

GNS

0.937

ARSA

0.936

STS

0.934

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSA	ARSB	ENSP00000216124	ENSP00000264914	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	0.936
ARSA	ARSD	ENSP00000216124	ENSP00000370546	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase D; Sulfatases	0.922
ARSA	ARSH	ENSP00000216124	ENSP00000370522	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase family member H; Sulfatases	0.924
ARSA	ARSK	ENSP00000216124	ENSP00000369346	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase family member K; Sulfatases	0.925
ARSA	GNS	ENSP00000216124	ENSP00000258145	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family	0.925
ARSA	GUSB	ENSP00000216124	ENSP00000302728	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family	0.954
ARSA	IDUA	ENSP00000216124	ENSP00000247933	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Alpha-L-iduronidase; Iduronidase, alpha-L-	0.572
ARSA	STS	ENSP00000216124	ENSP00000217961	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases	0.917
ARSA	SUMF1	ENSP00000216124	ENSP00000272902	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family	0.980
ARSA	SUMF2	ENSP00000216124	ENSP00000341938	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Sulfatase-modifying factor 2; Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1	0.957
ARSB	ARSA	ENSP00000264914	ENSP00000216124	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	0.936
ARSB	ARSD	ENSP00000264914	ENSP00000370546	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase D; Sulfatases	0.937
ARSB	ARSH	ENSP00000264914	ENSP00000370522	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase family member H; Sulfatases	0.941
ARSB	ARSK	ENSP00000264914	ENSP00000369346	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase family member K; Sulfatases	0.949
ARSB	GNS	ENSP00000264914	ENSP00000258145	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family	0.937
ARSB	GUSB	ENSP00000264914	ENSP00000302728	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family	0.962
ARSB	IDUA	ENSP00000264914	ENSP00000247933	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Alpha-L-iduronidase; Iduronidase, alpha-L-	0.966
ARSB	STS	ENSP00000264914	ENSP00000217961	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases	0.934
ARSB	SUMF1	ENSP00000264914	ENSP00000272902	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family	0.976
ARSB	SUMF2	ENSP00000264914	ENSP00000341938	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Sulfatase-modifying factor 2; Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1	0.951

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