| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCA13 | RILPL1 | ENSP00000411096 | ENSP00000366070 | ATP binding cassette subfamily A member 13 | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution; Belongs to the RILPL family | 0.686 |
| ABCA13 | TBC1D19 | ENSP00000411096 | ENSP00000264866 | ATP binding cassette subfamily A member 13 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.720 |
| CCKAR | STIM2 | ENSP00000295589 | ENSP00000417569 | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | Stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | 0.659 |
| CCKAR | TBC1D19 | ENSP00000295589 | ENSP00000264866 | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.725 |
| LRRC49 | NICN1 | ENSP00000453273 | ENSP00000273598 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Nicolin-1; Nicolin 1 | 0.982 |
| LRRC49 | TBC1D19 | ENSP00000453273 | ENSP00000264866 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.843 |
| LRRC49 | TTLL1 | ENSP00000453273 | ENSP00000266254 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.983 |
| NICN1 | LRRC49 | ENSP00000273598 | ENSP00000453273 | Nicolin-1; Nicolin 1 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.982 |
| NICN1 | TBC1D19 | ENSP00000273598 | ENSP00000264866 | Nicolin-1; Nicolin 1 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.829 |
| NICN1 | TTLL1 | ENSP00000273598 | ENSP00000266254 | Nicolin-1; Nicolin 1 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.986 |
| RILPL1 | ABCA13 | ENSP00000366070 | ENSP00000411096 | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution; Belongs to the RILPL family | ATP binding cassette subfamily A member 13 | 0.686 |
| RILPL1 | TBC1D19 | ENSP00000366070 | ENSP00000264866 | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution; Belongs to the RILPL family | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.720 |
| STIM2 | CCKAR | ENSP00000417569 | ENSP00000295589 | Stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | 0.659 |
| STIM2 | TBC1D19 | ENSP00000417569 | ENSP00000264866 | Stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.713 |
| TBC1D13 | TBC1D19 | ENSP00000361731 | ENSP00000264866 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | 0.653 |
| TBC1D13 | TBC1D30 | ENSP00000361731 | ENSP00000440207 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro | 0.593 |
| TBC1D19 | ABCA13 | ENSP00000264866 | ENSP00000411096 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | ATP binding cassette subfamily A member 13 | 0.720 |
| TBC1D19 | CCKAR | ENSP00000264866 | ENSP00000295589 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | 0.725 |
| TBC1D19 | LRRC49 | ENSP00000264866 | ENSP00000453273 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.843 |
| TBC1D19 | NICN1 | ENSP00000264866 | ENSP00000273598 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) | Nicolin-1; Nicolin 1 | 0.829 |
