| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COL4A3BP | GPBP1 | ENSP00000369862 | ENSP00000264779 | Collagen type IV alpha-3-binding protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner; Pleckstrin homology domain containing | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | 0.560 |
| DRG2 | GPBP1 | ENSP00000225729 | ENSP00000264779 | Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | 0.590 |
| DRG2 | PSMC1 | ENSP00000225729 | ENSP00000261303 | Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family | 26S proteasome regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 0.574 |
| DRG2 | TNIP3 | ENSP00000225729 | ENSP00000426613 | Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family | TNFAIP3-interacting protein 3; Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding | 0.643 |
| DRG2 | ZCCHC4 | ENSP00000225729 | ENSP00000303468 | Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family | Zinc finger CCHC domain-containing protein 4; May be a methyltransferase; Seven-beta-strand methyltransferase motif containing | 0.757 |
| EP300 | GPBP1 | ENSP00000263253 | ENSP00000264779 | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at ’Lys-122’ (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at ’Lys-27’ (H3K [...] | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | 0.608 |
| EP300 | GTF2B | ENSP00000263253 | ENSP00000359531 | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at ’Lys-122’ (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at ’Lys-27’ (H3K [...] | Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family | 0.765 |
| GPBP1 | COL4A3BP | ENSP00000264779 | ENSP00000369862 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | Collagen type IV alpha-3-binding protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner; Pleckstrin homology domain containing | 0.560 |
| GPBP1 | DRG2 | ENSP00000264779 | ENSP00000225729 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family | 0.590 |
| GPBP1 | EP300 | ENSP00000264779 | ENSP00000263253 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at ’Lys-122’ (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at ’Lys-27’ (H3K [...] | 0.608 |
| GPBP1 | GTF2B | ENSP00000264779 | ENSP00000359531 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family | 0.675 |
| GPBP1 | PSMC1 | ENSP00000264779 | ENSP00000261303 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | 26S proteasome regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 0.584 |
| GPBP1 | RPL22 | ENSP00000264779 | ENSP00000346088 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family | 0.558 |
| GPBP1 | TNIP3 | ENSP00000264779 | ENSP00000426613 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | TNFAIP3-interacting protein 3; Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding | 0.657 |
| GPBP1 | TOP2A | ENSP00000264779 | ENSP00000411532 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity); Topoisomerases | 0.725 |
| GPBP1 | ZCCHC10 | ENSP00000264779 | ENSP00000423276 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | Zinc finger CCHC-type containing 10 | 0.560 |
| GPBP1 | ZCCHC4 | ENSP00000264779 | ENSP00000303468 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | Zinc finger CCHC domain-containing protein 4; May be a methyltransferase; Seven-beta-strand methyltransferase motif containing | 0.590 |
| GTF2B | EP300 | ENSP00000359531 | ENSP00000263253 | Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at ’Lys-122’ (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at ’Lys-27’ (H3K [...] | 0.765 |
| GTF2B | GPBP1 | ENSP00000359531 | ENSP00000264779 | Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family | 0.675 |
| PSMC1 | DRG2 | ENSP00000261303 | ENSP00000225729 | 26S proteasome regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family | 0.574 |
