FNDC4 protein (human) - STRING database

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FNDC4

Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing (234 aa)

Predicted Functional Partners:

ZNF512

0.801

C2orf16

0.758

XKR6

0.730

LDLRAP1

0.693

IFT172

0.608

TUSC1

0.592

FN1

0.569

EIF2B4

0.557

KRTCAP3

0.533

CCDC61

0.527

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2orf16	EIF2B4	ENSP00000386190	ENSP00000394869	Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16	Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP	0.448
C2orf16	FNDC4	ENSP00000386190	ENSP00000264703	Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	0.758
C2orf16	LDLRAP1	ENSP00000386190	ENSP00000363458	Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16	Low density lipoprotein receptor adapter protein 1; Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalizat [...]	0.447
C2orf16	XKR6	ENSP00000386190	ENSP00000416707	Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16	XK-related protein 6; XK related family; Belongs to the XK family	0.658
C2orf16	ZNF512	ENSP00000386190	ENSP00000347648	Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16	Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.784
CCDC61	FNDC4	ENSP00000471454	ENSP00000264703	Coiled-coil domain containing 61	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	0.527
EIF2B4	C2orf16	ENSP00000394869	ENSP00000386190	Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP	Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16	0.448
EIF2B4	FNDC4	ENSP00000394869	ENSP00000264703	Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	0.557
EIF2B4	KRTCAP3	ENSP00000394869	ENSP00000442400	Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP	Keratinocyte associated protein 3	0.486
EIF2B4	ZNF512	ENSP00000394869	ENSP00000347648	Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP	Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.532
FN1	FNDC4	ENSP00000346839	ENSP00000264703	Fibronectin type III domain containing; Endogenous ligands	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	0.569
FNDC4	C2orf16	ENSP00000264703	ENSP00000386190	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16	0.758
FNDC4	CCDC61	ENSP00000264703	ENSP00000471454	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Coiled-coil domain containing 61	0.527
FNDC4	EIF2B4	ENSP00000264703	ENSP00000394869	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP	0.557
FNDC4	FN1	ENSP00000264703	ENSP00000346839	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Fibronectin type III domain containing; Endogenous ligands	0.569
FNDC4	IFT172	ENSP00000264703	ENSP00000260570	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family	0.608
FNDC4	KRTCAP3	ENSP00000264703	ENSP00000442400	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Keratinocyte associated protein 3	0.533
FNDC4	LDLRAP1	ENSP00000264703	ENSP00000363458	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Low density lipoprotein receptor adapter protein 1; Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalizat [...]	0.693
FNDC4	TUSC1	ENSP00000264703	ENSP00000350716	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	Tumor suppressor candidate 1	0.592
FNDC4	XKR6	ENSP00000264703	ENSP00000416707	Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis; Fibronectin type III domain containing	XK-related protein 6; XK related family; Belongs to the XK family	0.730

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