• Version:
  • 11.0 [archived version]
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CORO6 CORO6 MAP6D1 MAP6D1 CISD3 CISD3 REM2 REM2 RAPGEFL1 RAPGEFL1 KIAA1522 KIAA1522 RGL4 RGL4 SIPA1 SIPA1 KNDC1 KNDC1 VAT1L VAT1L RRAD RRAD
"RAPGEFL1" - Rap guanine nucleotide exchange factor-like 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
RAPGEFL1Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) (456 aa)    
Predicted Functional Partners:
KNDC1
Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (1749 aa)
     
   
  0.754
RRAD
GTP-binding protein RAD; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D; Belongs to the small GTPase superfamily. RGK family (308 aa)
       
 
  0.649
SIPA1
Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity); PDZ domain containing (1042 aa)
           
  0.551
MAP6D1
MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family (199 aa)
     
   
  0.545
RGL4
Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4 (473 aa)
           
  0.522
CORO6
Coronin-6; WD repeat domain containing; Coronins (472 aa)
     
   
  0.464
REM2
GTP-binding protein REM 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis; Belongs to the small GTPase superfamily. RGK family (340 aa)
       
 
  0.454
VAT1L
Synaptic vesicle membrane protein VAT-1 homolog-like; Vesicle amine transport 1 like; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily (419 aa)
     
   
  0.427
CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial; CDGSH iron sulfur domain containing; Belongs to the CISD protein family (127 aa)
           
  0.416
KIAA1522
Uncharacterized protein KIAA1522; KIAA1522 (1094 aa)
     
   
  0.407
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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