node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CISD3 | RAPGEFL1 | ENSP00000483781 | ENSP00000264644 | CDGSH iron-sulfur domain-containing protein 3, mitochondrial; CDGSH iron sulfur domain containing; Belongs to the CISD protein family | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | 0.416 |
CORO6 | MAP6D1 | ENSP00000344562 | ENSP00000314560 | Coronin-6; WD repeat domain containing; Coronins | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family | 0.582 |
CORO6 | RAPGEFL1 | ENSP00000344562 | ENSP00000264644 | Coronin-6; WD repeat domain containing; Coronins | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | 0.464 |
KIAA1522 | RAPGEFL1 | ENSP00000383851 | ENSP00000264644 | Uncharacterized protein KIAA1522; KIAA1522 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | 0.407 |
KNDC1 | RAPGEFL1 | ENSP00000304437 | ENSP00000264644 | Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | 0.754 |
KNDC1 | RGL4 | ENSP00000304437 | ENSP00000290691 | Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4 | 0.470 |
KNDC1 | RRAD | ENSP00000304437 | ENSP00000299759 | Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence | GTP-binding protein RAD; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D; Belongs to the small GTPase superfamily. RGK family | 0.530 |
KNDC1 | SIPA1 | ENSP00000304437 | ENSP00000377771 | Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence | Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity); PDZ domain containing | 0.526 |
MAP6D1 | CORO6 | ENSP00000314560 | ENSP00000344562 | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family | Coronin-6; WD repeat domain containing; Coronins | 0.582 |
MAP6D1 | RAPGEFL1 | ENSP00000314560 | ENSP00000264644 | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | 0.545 |
RAPGEFL1 | CISD3 | ENSP00000264644 | ENSP00000483781 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | CDGSH iron-sulfur domain-containing protein 3, mitochondrial; CDGSH iron sulfur domain containing; Belongs to the CISD protein family | 0.416 |
RAPGEFL1 | CORO6 | ENSP00000264644 | ENSP00000344562 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | Coronin-6; WD repeat domain containing; Coronins | 0.464 |
RAPGEFL1 | KIAA1522 | ENSP00000264644 | ENSP00000383851 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | Uncharacterized protein KIAA1522; KIAA1522 | 0.407 |
RAPGEFL1 | KNDC1 | ENSP00000264644 | ENSP00000304437 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence | 0.754 |
RAPGEFL1 | MAP6D1 | ENSP00000264644 | ENSP00000314560 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family | 0.545 |
RAPGEFL1 | REM2 | ENSP00000264644 | ENSP00000267396 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | GTP-binding protein REM 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis; Belongs to the small GTPase superfamily. RGK family | 0.454 |
RAPGEFL1 | RGL4 | ENSP00000264644 | ENSP00000290691 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4 | 0.522 |
RAPGEFL1 | RRAD | ENSP00000264644 | ENSP00000299759 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | GTP-binding protein RAD; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D; Belongs to the small GTPase superfamily. RGK family | 0.649 |
RAPGEFL1 | SIPA1 | ENSP00000264644 | ENSP00000377771 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity); PDZ domain containing | 0.551 |
RAPGEFL1 | VAT1L | ENSP00000264644 | ENSP00000303129 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) | Synaptic vesicle membrane protein VAT-1 homolog-like; Vesicle amine transport 1 like; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily | 0.427 |