CSTA protein (human) - STRING database

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CSTA

Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family (98 aa)

Predicted Functional Partners:

CTSB

0.977

IVL

0.960

LOR

0.955

TGM1

0.954

CTSL

0.952

PI3

0.947

DSP

0.937

FLG

0.937

CDSN

0.935

EVPL

0.934

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDSN	CSTA	ENSP00000365465	ENSP00000264474	Corneodesmosin; Important for the epidermal barrier integrity	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	0.935
CDSN	DSP	ENSP00000365465	ENSP00000369129	Corneodesmosin; Important for the epidermal barrier integrity	Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family	0.503
CDSN	EVPL	ENSP00000365465	ENSP00000301607	Corneodesmosin; Important for the epidermal barrier integrity	Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins	0.948
CDSN	FLG	ENSP00000365465	ENSP00000357789	Corneodesmosin; Important for the epidermal barrier integrity	Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing	0.676
CDSN	IVL	ENSP00000365465	ENSP00000357753	Corneodesmosin; Important for the epidermal barrier integrity	Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family	0.956
CDSN	LOR	ENSP00000365465	ENSP00000357731	Corneodesmosin; Important for the epidermal barrier integrity	Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family	0.965
CDSN	PI3	ENSP00000365465	ENSP00000243924	Corneodesmosin; Important for the epidermal barrier integrity	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing	0.907
CDSN	TGM1	ENSP00000365465	ENSP00000206765	Corneodesmosin; Important for the epidermal barrier integrity	Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family	0.951
CSTA	CDSN	ENSP00000264474	ENSP00000365465	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Corneodesmosin; Important for the epidermal barrier integrity	0.935
CSTA	CTSB	ENSP00000264474	ENSP00000345672	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins	0.977
CSTA	CTSL	ENSP00000264474	ENSP00000345344	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Cathepsin L1; Important for the overall degradation of proteins in lysosomes; Cathepsins	0.952
CSTA	DSP	ENSP00000264474	ENSP00000369129	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family	0.937
CSTA	EVPL	ENSP00000264474	ENSP00000301607	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins	0.934
CSTA	FLG	ENSP00000264474	ENSP00000357789	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing	0.937
CSTA	IVL	ENSP00000264474	ENSP00000357753	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family	0.960
CSTA	LOR	ENSP00000264474	ENSP00000357731	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family	0.955
CSTA	PI3	ENSP00000264474	ENSP00000243924	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing	0.947
CSTA	TGM1	ENSP00000264474	ENSP00000206765	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family	0.954
CTSB	CSTA	ENSP00000345672	ENSP00000264474	Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	0.977
CTSB	CTSL	ENSP00000345672	ENSP00000345344	Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins	Cathepsin L1; Important for the overall degradation of proteins in lysosomes; Cathepsins	0.904

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