| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHAT | SLC18A3 | ENSP00000337103 | ENSP00000363229 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | 0.956 |
| CHAT | SLC5A7 | ENSP00000337103 | ENSP00000264047 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.748 |
| CHIT1 | SLC5A7 | ENSP00000356198 | ENSP00000264047 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.710 |
| ENSG00000279515 | SLC5A7 | ENSP00000485520 | ENSP00000264047 | HCG1732469; Putative uncharacterized protein FLJ20019 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.800 |
| ENSG00000279515 | ST6GAL2 | ENSP00000485520 | ENSP00000386942 | HCG1732469; Putative uncharacterized protein FLJ20019 | Beta-galactoside alpha-2,6-sialyltransferase 2; Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids; Belongs to the glycosyltransferase 29 family | 0.580 |
| MN1 | SLC5A7 | ENSP00000304956 | ENSP00000264047 | Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable) | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.743 |
| PLEKHG5 | SLC5A7 | ENSP00000439625 | ENSP00000264047 | Pleckstrin homology domain-containing family G member 5; Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis; Pleckstrin homology domain containing | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.711 |
| RAB38 | SLC5A7 | ENSP00000243662 | ENSP00000264047 | Ras-related protein Rab-38; May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzyme [...] | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.754 |
| SLC18A3 | CHAT | ENSP00000363229 | ENSP00000337103 | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family | 0.956 |
| SLC18A3 | SLC44A4 | ENSP00000363229 | ENSP00000229729 | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota- generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis; Deafness associated genes | 0.487 |
| SLC18A3 | SLC5A7 | ENSP00000363229 | ENSP00000264047 | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.920 |
| SLC44A1 | SLC5A7 | ENSP00000363852 | ENSP00000264047 | Choline transporter-like protein 1; Choline transporter. May be involved in membrane synthesis and myelin production; Belongs to the CTL (choline transporter-like) family | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.690 |
| SLC44A4 | SLC18A3 | ENSP00000229729 | ENSP00000363229 | Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota- generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis; Deafness associated genes | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | 0.487 |
| SLC44A4 | SLC5A7 | ENSP00000229729 | ENSP00000264047 | Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota- generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis; Deafness associated genes | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.733 |
| SLC5A7 | CHAT | ENSP00000264047 | ENSP00000337103 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family | 0.748 |
| SLC5A7 | CHIT1 | ENSP00000264047 | ENSP00000356198 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | 0.710 |
| SLC5A7 | ENSG00000279515 | ENSP00000264047 | ENSP00000485520 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | HCG1732469; Putative uncharacterized protein FLJ20019 | 0.800 |
| SLC5A7 | MN1 | ENSP00000264047 | ENSP00000304956 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable) | 0.743 |
| SLC5A7 | PLEKHG5 | ENSP00000264047 | ENSP00000439625 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Pleckstrin homology domain-containing family G member 5; Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis; Pleckstrin homology domain containing | 0.711 |
| SLC5A7 | RAB38 | ENSP00000264047 | ENSP00000243662 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Ras-related protein Rab-38; May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzyme [...] | 0.754 |
