STRN protein (human) - STRING database

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STRN

Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family (780 aa)

Predicted Functional Partners:

MOB4

0.995

STRIP1

0.976

SLMAP

0.974

STRIP2

0.973

STK24

0.972

MST4

0.965

STK25

0.961

CTTNBP2NL

0.954

ESR1

0.954

PPP2R1A

0.951

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTTNBP2NL	MOB4	ENSP00000271277	ENSP00000315702	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	0.952
CTTNBP2NL	MST4	ENSP00000271277	ENSP00000377867	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily	0.929
CTTNBP2NL	PPP2R1A	ENSP00000271277	ENSP00000324804	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis	0.890
CTTNBP2NL	SLMAP	ENSP00000271277	ENSP00000295951	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Sarcolemmal membrane-associated protein; May play a role during myoblast fusion; STRIPAK complex	0.718
CTTNBP2NL	STK24	ENSP00000271277	ENSP00000365730	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and sti [...]	0.908
CTTNBP2NL	STK25	ENSP00000271277	ENSP00000325748	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration	0.904
CTTNBP2NL	STRIP1	ENSP00000271277	ENSP00000358810	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape; STRIPAK complex	0.960
CTTNBP2NL	STRIP2	ENSP00000271277	ENSP00000249344	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Belongs to the STRIP family	0.958
CTTNBP2NL	STRN	ENSP00000271277	ENSP00000263918	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family	0.954
ESR1	PPP2R1A	ENSP00000405330	ENSP00000324804	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis	0.508
ESR1	STRN	ENSP00000405330	ENSP00000263918	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family	0.954
MOB4	CTTNBP2NL	ENSP00000315702	ENSP00000271277	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	0.952
MOB4	MST4	ENSP00000315702	ENSP00000377867	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily	0.952
MOB4	PPP2R1A	ENSP00000315702	ENSP00000324804	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis	0.937
MOB4	SLMAP	ENSP00000315702	ENSP00000295951	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Sarcolemmal membrane-associated protein; May play a role during myoblast fusion; STRIPAK complex	0.953
MOB4	STK24	ENSP00000315702	ENSP00000365730	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Serine/threonine-protein kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and sti [...]	0.944
MOB4	STK25	ENSP00000315702	ENSP00000325748	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration	0.947
MOB4	STRIP1	ENSP00000315702	ENSP00000358810	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape; STRIPAK complex	0.970
MOB4	STRIP2	ENSP00000315702	ENSP00000249344	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Belongs to the STRIP family	0.962
MOB4	STRN	ENSP00000315702	ENSP00000263918	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family	0.995

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