| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KNOP1 | ZNF106 | ENSP00000219837 | ENSP00000263805 | Lysine rich nucleolar protein 1 | Zinc finger protein 106; WD repeat domain containing | 0.578 |
| MDC1 | TP53BP1 | ENSP00000365588 | ENSP00000371475 | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ’Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be a [...] | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.998 |
| MDC1 | ZNF106 | ENSP00000365588 | ENSP00000263805 | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ’Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be a [...] | Zinc finger protein 106; WD repeat domain containing | 0.690 |
| NRF1 | ZNF106 | ENSP00000376924 | ENSP00000263805 | Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication | Zinc finger protein 106; WD repeat domain containing | 0.656 |
| PDCL3 | ZNF106 | ENSP00000264254 | ENSP00000263805 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | Zinc finger protein 106; WD repeat domain containing | 0.520 |
| RBM7 | ZNF106 | ENSP00000364639 | ENSP00000263805 | RNA-binding protein 7; Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA- binding protein adapters. Possible involved in germ cell RNA processing and meiosis (Probable) | Zinc finger protein 106; WD repeat domain containing | 0.494 |
| SSR4 | ZNF106 | ENSP00000317331 | ENSP00000263805 | Translocon-associated protein subunit delta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Belongs to the TRAP-delta family | Zinc finger protein 106; WD repeat domain containing | 0.506 |
| TP53BP1 | MDC1 | ENSP00000371475 | ENSP00000365588 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ’Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be a [...] | 0.998 |
| TP53BP1 | ZNF106 | ENSP00000371475 | ENSP00000263805 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | Zinc finger protein 106; WD repeat domain containing | 0.575 |
| TRAP1 | ZNF106 | ENSP00000246957 | ENSP00000263805 | Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA; Belongs to the heat shock protein 90 family | Zinc finger protein 106; WD repeat domain containing | 0.491 |
| ZNF106 | KNOP1 | ENSP00000263805 | ENSP00000219837 | Zinc finger protein 106; WD repeat domain containing | Lysine rich nucleolar protein 1 | 0.578 |
| ZNF106 | MDC1 | ENSP00000263805 | ENSP00000365588 | Zinc finger protein 106; WD repeat domain containing | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ’Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be a [...] | 0.690 |
| ZNF106 | NRF1 | ENSP00000263805 | ENSP00000376924 | Zinc finger protein 106; WD repeat domain containing | Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication | 0.656 |
| ZNF106 | PDCL3 | ENSP00000263805 | ENSP00000264254 | Zinc finger protein 106; WD repeat domain containing | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | 0.520 |
| ZNF106 | RBM7 | ENSP00000263805 | ENSP00000364639 | Zinc finger protein 106; WD repeat domain containing | RNA-binding protein 7; Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA- binding protein adapters. Possible involved in germ cell RNA processing and meiosis (Probable) | 0.494 |
| ZNF106 | SSR4 | ENSP00000263805 | ENSP00000317331 | Zinc finger protein 106; WD repeat domain containing | Translocon-associated protein subunit delta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Belongs to the TRAP-delta family | 0.506 |
| ZNF106 | TP53BP1 | ENSP00000263805 | ENSP00000371475 | Zinc finger protein 106; WD repeat domain containing | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.575 |
| ZNF106 | TRAP1 | ENSP00000263805 | ENSP00000246957 | Zinc finger protein 106; WD repeat domain containing | Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA; Belongs to the heat shock protein 90 family | 0.491 |
| ZNF106 | ZNF175 | ENSP00000263805 | ENSP00000262259 | Zinc finger protein 106; WD repeat domain containing | Zinc finger protein 175; Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat- induced viral LTR promoter activity; Zinc fingers C2H2-type | 0.493 |
| ZNF106 | ZNF91 | ENSP00000263805 | ENSP00000300619 | Zinc finger protein 106; WD repeat domain containing | Zinc finger protein 91; Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons- recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1. May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.800 |
