CHRDL2 protein (human) - STRING database

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CHRDL2

Chordin-related protein 2 variant III; Chordin like 2 (451 aa)

Predicted Functional Partners:

BMP2

0.912

AQPEP

0.757

TWSG1

0.720

BMP5

0.717

FSTL5

0.703

BMP6

0.664

XRRA1

0.660

SOSTDC1

0.651

SOST

0.648

GDF5

0.644

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQPEP	CHRDL2	ENSP00000350541	ENSP00000263671	Aminopeptidase Q; Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met- MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C	Chordin-related protein 2 variant III; Chordin like 2	0.757
BMP2	BMP5	ENSP00000368104	ENSP00000359866	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family	Bone morphogenetic protein 5; Induces cartilage and bone formation; Bone morphogenetic proteins	0.931
BMP2	CHRDL2	ENSP00000368104	ENSP00000263671	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family	Chordin-related protein 2 variant III; Chordin like 2	0.912
BMP2	SOST	ENSP00000368104	ENSP00000301691	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family	Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation; DAN family	0.930
BMP2	SOSTDC1	ENSP00000368104	ENSP00000304930	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family	Sclerostin domain-containing protein 1; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner; DAN family	0.956
BMP2	TWSG1	ENSP00000368104	ENSP00000262120	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family	Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity)	0.801
BMP5	BMP2	ENSP00000359866	ENSP00000368104	Bone morphogenetic protein 5; Induces cartilage and bone formation; Bone morphogenetic proteins	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family	0.931
BMP5	CHRDL2	ENSP00000359866	ENSP00000263671	Bone morphogenetic protein 5; Induces cartilage and bone formation; Bone morphogenetic proteins	Chordin-related protein 2 variant III; Chordin like 2	0.717
BMP5	SOST	ENSP00000359866	ENSP00000301691	Bone morphogenetic protein 5; Induces cartilage and bone formation; Bone morphogenetic proteins	Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation; DAN family	0.920
BMP5	TWSG1	ENSP00000359866	ENSP00000262120	Bone morphogenetic protein 5; Induces cartilage and bone formation; Bone morphogenetic proteins	Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity)	0.768
BMP6	CHRDL2	ENSP00000283147	ENSP00000263671	Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins	Chordin-related protein 2 variant III; Chordin like 2	0.664
BMP6	SOST	ENSP00000283147	ENSP00000301691	Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins	Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation; DAN family	0.900
BMP6	SOSTDC1	ENSP00000283147	ENSP00000304930	Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins	Sclerostin domain-containing protein 1; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner; DAN family	0.603
BMP6	TWSG1	ENSP00000283147	ENSP00000262120	Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins	Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity)	0.708
CHRDL2	AQPEP	ENSP00000263671	ENSP00000350541	Chordin-related protein 2 variant III; Chordin like 2	Aminopeptidase Q; Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met- MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C	0.757
CHRDL2	BMP2	ENSP00000263671	ENSP00000368104	Chordin-related protein 2 variant III; Chordin like 2	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family	0.912
CHRDL2	BMP5	ENSP00000263671	ENSP00000359866	Chordin-related protein 2 variant III; Chordin like 2	Bone morphogenetic protein 5; Induces cartilage and bone formation; Bone morphogenetic proteins	0.717
CHRDL2	BMP6	ENSP00000263671	ENSP00000283147	Chordin-related protein 2 variant III; Chordin like 2	Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins	0.664
CHRDL2	FSTL5	ENSP00000263671	ENSP00000305334	Chordin-related protein 2 variant III; Chordin like 2	Follistatin-related protein 5; EF-hand domain containing	0.703
CHRDL2	GDF5	ENSP00000263671	ENSP00000363492	Chordin-related protein 2 variant III; Chordin like 2	Growth/differentiation factor 5; Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upo [...]	0.644

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