node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATOH1 | BARHL1 | ENSP00000302216 | ENSP00000263610 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | 0.699 |
ATOH1 | CNTN2 | ENSP00000302216 | ENSP00000330633 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | Contactin-2; In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion; Fibronectin type III domain containing | 0.471 |
ATOH1 | LHX1 | ENSP00000302216 | ENSP00000477829 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes | 0.462 |
ATOH1 | LHX2 | ENSP00000302216 | ENSP00000362717 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | LIM/homeobox protein Lhx2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity); LIM class homeoboxes | 0.480 |
ATOH1 | LHX9 | ENSP00000302216 | ENSP00000356357 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | LIM/homeobox protein Lhx9; Involved in gonadal development; LIM class homeoboxes | 0.463 |
ATOH1 | LMX1A | ENSP00000302216 | ENSP00000340226 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | LIM homeobox transcription factor 1-alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity); LIM class homeoboxes | 0.513 |
ATOH1 | POU4F3 | ENSP00000302216 | ENSP00000230732 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5’-ATGCAAAT-3’ in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity); Belongs to the POU transcription factor family. Class- 4 subfamily | 0.867 |
ATOH1 | WNT1 | ENSP00000302216 | ENSP00000293549 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development | 0.561 |
BARHL1 | ATOH1 | ENSP00000263610 | ENSP00000302216 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | 0.699 |
BARHL1 | CNTN2 | ENSP00000263610 | ENSP00000330633 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | Contactin-2; In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion; Fibronectin type III domain containing | 0.539 |
BARHL1 | KIRREL3 | ENSP00000263610 | ENSP00000435466 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | Kin of IRRE-like protein 3; Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target- specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic sup [...] | 0.578 |
BARHL1 | LHX1 | ENSP00000263610 | ENSP00000477829 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes | 0.527 |
BARHL1 | LHX2 | ENSP00000263610 | ENSP00000362717 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | LIM/homeobox protein Lhx2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity); LIM class homeoboxes | 0.606 |
BARHL1 | LHX9 | ENSP00000263610 | ENSP00000356357 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | LIM/homeobox protein Lhx9; Involved in gonadal development; LIM class homeoboxes | 0.665 |
BARHL1 | LMX1A | ENSP00000263610 | ENSP00000340226 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | LIM homeobox transcription factor 1-alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity); LIM class homeoboxes | 0.562 |
BARHL1 | POU4F3 | ENSP00000263610 | ENSP00000230732 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5’-ATGCAAAT-3’ in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity); Belongs to the POU transcription factor family. Class- 4 subfamily | 0.686 |
BARHL1 | RPGRIP1L | ENSP00000263610 | ENSP00000369257 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | Protein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left- right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled protein [...] | 0.532 |
BARHL1 | WNT1 | ENSP00000263610 | ENSP00000293549 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development | 0.543 |
CNTN2 | ATOH1 | ENSP00000330633 | ENSP00000302216 | Contactin-2; In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion; Fibronectin type III domain containing | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity); Basic helix-loop-helix proteins | 0.471 |
CNTN2 | BARHL1 | ENSP00000330633 | ENSP00000263610 | Contactin-2; In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion; Fibronectin type III domain containing | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes | 0.539 |