DDX18 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DDX18

ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily (670 aa)

Predicted Functional Partners:

NIFK

0.997

NOP58

0.994

GTPBP4

0.992

NOP2

0.992

BRIX1

0.990

RPF2

0.990

NIP7

0.989

BOP1

0.988

TBL3

0.988

NSA2

0.987

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	BRIX1	ENSP00000455106	ENSP00000338862	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	0.990
BOP1	DDX18	ENSP00000455106	ENSP00000263239	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	0.988
BOP1	GTPBP4	ENSP00000455106	ENSP00000354040	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.986
BOP1	NIFK	ENSP00000455106	ENSP00000285814	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.990
BOP1	NIP7	ENSP00000455106	ENSP00000254940	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family	0.988
BOP1	NOP2	ENSP00000455106	ENSP00000371858	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.997
BOP1	NOP58	ENSP00000455106	ENSP00000264279	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family	0.999
BOP1	NSA2	ENSP00000455106	ENSP00000483484	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)	0.989
BOP1	RPF2	ENSP00000455106	ENSP00000402338	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.971
BOP1	TBL3	ENSP00000455106	ENSP00000454836	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Transducin beta-like protein 3; WD repeat domain containing; UTPb subcomplex	0.991
BRIX1	BOP1	ENSP00000338862	ENSP00000455106	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	0.990
BRIX1	DDX18	ENSP00000338862	ENSP00000263239	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	0.990
BRIX1	GTPBP4	ENSP00000338862	ENSP00000354040	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.986
BRIX1	NIFK	ENSP00000338862	ENSP00000285814	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.998
BRIX1	NIP7	ENSP00000338862	ENSP00000254940	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family	0.982
BRIX1	NOP2	ENSP00000338862	ENSP00000371858	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.994
BRIX1	NOP58	ENSP00000338862	ENSP00000264279	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family	0.991
BRIX1	NSA2	ENSP00000338862	ENSP00000483484	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)	0.994
BRIX1	RPF2	ENSP00000338862	ENSP00000402338	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.989
BRIX1	TBL3	ENSP00000338862	ENSP00000454836	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Transducin beta-like protein 3; WD repeat domain containing; UTPb subcomplex	0.893

page 1 of 6

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2020

Credits

Access

Info

About