| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC7 | CCDC92 | ENSP00000394394 | ENSP00000238156 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Coiled-coil domain containing 92 | 0.727 |
| ANAPC7 | PPM1F | ENSP00000394394 | ENSP00000263212 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis; Belongs to the PP2C family | 0.691 |
| ASCC2 | CRNKL1 | ENSP00000380877 | ENSP00000366557 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.719 |
| ASCC2 | CWF19L1 | ENSP00000380877 | ENSP00000326411 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | CWF19-like protein 1; CWF19 like 1, cell cycle control | 0.753 |
| ASCC2 | KANSL2 | ENSP00000380877 | ENSP00000415436 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription | 0.728 |
| ASCC2 | PPM1F | ENSP00000380877 | ENSP00000263212 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis; Belongs to the PP2C family | 0.709 |
| CAMK1 | PPM1F | ENSP00000256460 | ENSP00000263212 | Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in h [...] | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis; Belongs to the PP2C family | 0.734 |
| CCDC92 | ANAPC7 | ENSP00000238156 | ENSP00000394394 | Coiled-coil domain containing 92 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | 0.727 |
| CCDC92 | PPM1F | ENSP00000238156 | ENSP00000263212 | Coiled-coil domain containing 92 | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis; Belongs to the PP2C family | 0.739 |
| CRNKL1 | ASCC2 | ENSP00000366557 | ENSP00000380877 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | 0.719 |
| CRNKL1 | CWF19L1 | ENSP00000366557 | ENSP00000326411 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | CWF19-like protein 1; CWF19 like 1, cell cycle control | 0.773 |
| CRNKL1 | KANSL2 | ENSP00000366557 | ENSP00000415436 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription | 0.729 |
| CRNKL1 | PPM1F | ENSP00000366557 | ENSP00000263212 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis; Belongs to the PP2C family | 0.691 |
| CWF19L1 | ASCC2 | ENSP00000326411 | ENSP00000380877 | CWF19-like protein 1; CWF19 like 1, cell cycle control | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | 0.753 |
| CWF19L1 | CRNKL1 | ENSP00000326411 | ENSP00000366557 | CWF19-like protein 1; CWF19 like 1, cell cycle control | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.773 |
| CWF19L1 | KANSL2 | ENSP00000326411 | ENSP00000415436 | CWF19-like protein 1; CWF19 like 1, cell cycle control | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription | 0.773 |
| CWF19L1 | PPM1F | ENSP00000326411 | ENSP00000263212 | CWF19-like protein 1; CWF19 like 1, cell cycle control | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis; Belongs to the PP2C family | 0.730 |
| FEM1A | FEM1B | ENSP00000269856 | ENSP00000307298 | Protein fem-1 homolog A; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4; Ankyrin repeat domain containing | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family | 0.914 |
| FEM1A | PPM1F | ENSP00000269856 | ENSP00000263212 | Protein fem-1 homolog A; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4; Ankyrin repeat domain containing | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis; Belongs to the PP2C family | 0.770 |
| FEM1B | FEM1A | ENSP00000307298 | ENSP00000269856 | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family | Protein fem-1 homolog A; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4; Ankyrin repeat domain containing | 0.914 |
